TY - JOUR
T1 - Anti-p200 pemphigoid
T2 - Diagnosis and treatment of a case presenting as an inflammatory subepidermal blistering disease
AU - Egan, Conleth A.
AU - Yee, Carole
AU - Zillikens, Detlef
AU - Yancey, Kim B.
PY - 2002/5/1
Y1 - 2002/5/1
N2 - Anti-p200 pemphigoid is a recently defined subepidermal immunobullous disease. It is characterized by the binding of circulating IgG autoantibodies to the dermal side of 1 M NaCl split skin and by reactivity of these autoantibodies to a unique 200-kd antigen on immunoblot of dermal extract. On immunoelectron microscopic examination, these autoantibodies deposit at the lamina lucida-lamina densa interface. We describe the clinical, histologic, and immunopathologic features in a patient with anti-p200 pemphigoid, as well as his favorable response to treatment with systemic glucocorticosteroids and dapsone.
AB - Anti-p200 pemphigoid is a recently defined subepidermal immunobullous disease. It is characterized by the binding of circulating IgG autoantibodies to the dermal side of 1 M NaCl split skin and by reactivity of these autoantibodies to a unique 200-kd antigen on immunoblot of dermal extract. On immunoelectron microscopic examination, these autoantibodies deposit at the lamina lucida-lamina densa interface. We describe the clinical, histologic, and immunopathologic features in a patient with anti-p200 pemphigoid, as well as his favorable response to treatment with systemic glucocorticosteroids and dapsone.
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U2 - 10.1067/mjd.2002.120923
DO - 10.1067/mjd.2002.120923
M3 - Article
C2 - 12004326
AN - SCOPUS:0036587405
SN - 0190-9622
VL - 46
SP - 786
EP - 789
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 5
ER -