Anti-neuronal antibodies in acute pandysautonomia

Naoko Matsui, Takao Mitsui, Yasushi Ohshima, Kenji Yokoi, Makoto Kunishige, Fumikazu Yagi, Steven Vernino, Toshio Matsumoto, Ryuji Kaji

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


We encountered two patients with acute pandysautonomia who subacutely exhibited extensive autonomic dysfunction after antecedent infections. Although these patients had been suffering from autonomic disturbance for several months, they both had a good clinical course after plasma exchange and intravenous immunoglobulin therapy. Thin-layer chromatography (TLC)-immunostaining did not demonstrate any antibodies against gangliosides, but immunoblot analysis showed antibodies against a neuroblastoma cell line, SHSY5Y, in serum samples. Furthermore, ganglionic acetylcholine receptor autoantibodies were detected in one patient. These findings suggest that neuronal antibodies against the autonomic nervous system play an important role in the pathogenesis of acute pandysautonomia.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalInternal Medicine
Issue number1
StatePublished - 2010


  • Acute pandysautonomia
  • Anti-neuronal antibodies
  • Autonomic function tests
  • Autonomic neuropathy
  • Immunoblot analysis

ASJC Scopus subject areas

  • Internal Medicine


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