Abstract
N-Cyclohexyl-3-methoxyquinoxalin-2-carboxamide (QCM-13), a novel 5-HT 3 antagonist identified from a series of compounds with higher pA 2 (7.6) and good log P (2.91) value was screened in rodent models of depression such as forced swim test (FST), tail suspension test (TST), interaction studies with standard anti-depressants and confirmatory studies such as reversal of parthenolide induced depression and reserpine induced hypothermia. In FST (2 and 4 mg/kg) and TST (2 and 4 mg/kg), QCM-13 significantly reduced the duration of immobility in mice without affecting the base line locomotion. QCM-13 (2 and 4 mg/kg) was also found to have significant interaction with standard anti-depressants (fluoxetine and bupropion in FST and TST respectively). Further, reversal of parthenolide induced depression in mice and reserpine induced hypothermia in rat models indicate the serotonergic influence of QCM-13 for anti-depressant potential.
Original language | English (US) |
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Pages (from-to) | 619-626 |
Number of pages | 8 |
Journal | Indian Journal of Experimental Biology |
Volume | 49 |
Issue number | 8 |
State | Published - Aug 2011 |
Externally published | Yes |
Keywords
- 5-HT
- Antagonist
- Anti-depressant-like effect
- Depression
- Forced swim test
- Quinoxalin-2-carboxamide
- Serotonin
ASJC Scopus subject areas
- Biotechnology
- Molecular Biology
- Cell Biology