Anti-anxiety effect of a novel 5-HT3 receptor antagonist N-(benzo[d]thiazol-2-yl)-3-ethoxyquinoxalin-2-carboxamide (6k) using battery tests for anxiety in mice

Yeshwant Vijay Kurhe, Mahesh Radhakrishnan, Devadoss Thangaraj, Deepali Gupta

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Objective: To investigate the anti-anxiety activity of "6k", a novel 5-hydroxytryptamine type 3 (5-HT3 ) receptor antagonist in in mice. Materials and Methods: Anti-anxiety activity of "6k" (1,2, and 4 mg/kg, intraperitoneally (i.p.)) was evaluated in mice by behavioral tests such as elevated plus maze (EPM), open field test (OFT), light-dark box (L&D), and hole board test (HBT). Diazepam (2 mg/kg, i.p.) served as reference standard. Results: "6k"significantly (P < 0.05) increased the time and entries in open arm in EPM as compared to vehicle control group. Further, "6k"significantly (P < 0.05) increased the central and peripheral ambulation along with rearings and time in central area; whereas, reduced the fecal pellets in OFT as compared to vehicle control group. There was significant (P < 0.05) reduction in the latency to enter dark chamber; whereas, increased number of crossings and time in light chamber in L&D aversion test by treatment with "6k" as compared to vehicle control group. In HBT, "6k" significantly (P < 0.05) increased the number of head dipping and squares crossed; whereas, reduced the latency for first head dip and number of fecal pellets as compared to vehicle control group. Conclusion: A novel 5-HT 3 receptor antagonist has anti-anxiety action.

Original languageEnglish (US)
Pages (from-to)100-104
Number of pages5
JournalIndian Journal of Pharmacology
Volume46
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • 5-HT antagonist
  • Anxiety
  • Elevated plus maze
  • Hole board test
  • Open field test

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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