Abstract
OBJECTIVE: The objective of this study was to systematically review the literature on animal ototoxicity from ototopical medications. A secondary objective was to assess the relevance of animal data to the use of ototopical drops in clinical situations involving humans. STUDY DESIGN: We performed a MEDLINE search of the published literature using appropriate search terms to identify pertinent articles, which were reviewed, summarized, and tabulated. RESULTS: One hundred seventy-three articles were reviewed; 61 articles were appropriate to the study question and were further analyzed. CONCLUSIONS: Virtually all studies demonstrate that aminoglycoside antibiotics, when applied topically into the middle ear space, are ototoxic in experimental animals.
Original language | English (US) |
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Pages (from-to) | S57-S78 |
Journal | Otolaryngology - Head and Neck Surgery |
Volume | 130 |
Issue number | 3 SUPPL. |
DOIs | |
State | Published - Mar 2004 |
ASJC Scopus subject areas
- Surgery
- Otorhinolaryngology