TY - JOUR
T1 - AngiomiRs-Key regulators of angiogenesis
AU - Wang, Shusheng
AU - Olson, Eric N.
N1 - Funding Information:
We thank Jose Cabrera for graphics. This work was supported by grants from the National Institutes of Health, the Donald W Reynolds Clinical Cardiovascular Research Center, the Sandler Foundation for Asthma Research, and the Robert A Welch Foundation to ENO. SW was supported by a fellowship grant from the American Heart Association
PY - 2009/6
Y1 - 2009/6
N2 - The formation of new blood vessels through the process of angiogenesis is critical in vascular development and homeostasis. Aberrant angiogenesis leads to a variety of diseases, such as ischemia and cancer. Recent studies have revealed important roles for miRNAs in regulating endothelial cell (EC) function, especially angiogenesis. Mice with EC-specific deletion of Dicer, a key enzyme for generating miRNAs, display defective postnatal angiogenesis. Specific miRNAs (angiomiRs) have recently been shown to regulate angiogenesis in vivo. miRNA-126, an EC-restricted miRNA, regulates vascular integrity and developmental angiogenesis. miR-378, miR-296, and the miR-17∼92 cluster contribute to tumor angiogenesis. Manipulating angiomiRs in the settings of pathological vascularization represents a new therapeutic approach.
AB - The formation of new blood vessels through the process of angiogenesis is critical in vascular development and homeostasis. Aberrant angiogenesis leads to a variety of diseases, such as ischemia and cancer. Recent studies have revealed important roles for miRNAs in regulating endothelial cell (EC) function, especially angiogenesis. Mice with EC-specific deletion of Dicer, a key enzyme for generating miRNAs, display defective postnatal angiogenesis. Specific miRNAs (angiomiRs) have recently been shown to regulate angiogenesis in vivo. miRNA-126, an EC-restricted miRNA, regulates vascular integrity and developmental angiogenesis. miR-378, miR-296, and the miR-17∼92 cluster contribute to tumor angiogenesis. Manipulating angiomiRs in the settings of pathological vascularization represents a new therapeutic approach.
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U2 - 10.1016/j.gde.2009.04.002
DO - 10.1016/j.gde.2009.04.002
M3 - Review article
C2 - 19446450
AN - SCOPUS:68649114571
SN - 0959-437X
VL - 19
SP - 205
EP - 211
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 3
ER -