Anaesthetic and forebrain modulation of raphe-coerulean interactions

A. McRae-Degueurce; C. M. Sinton

doi:10.1007/BF00236239

Anaesthetic and forebrain modulation of raphe-coerulean interactions

A. McRae-Degueurce, C. M. Sinton

Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Variations in tyrosine hydroxylase (TH) activity and serotonin (5-HT) content in the rat locus coeruleus were measured four days after lesion of the nucleus raphe centralis superior. Lesions were made under either ether or pentobarbital anaesthesia and, in addition, (under ether) in rats pretreated with atropine or with lesions of the medial septum. Results showed a dissociation between 5-HT reduction and TH induction, differences due to the anaesthetic used, and a possible influence from limbic centres on 5-HT in the LC. These findings are discussed in terms of the apparent complexity of raphe-coerulean interactions.

Original language	English (US)
Pages (from-to)	373-376
Number of pages	4
Journal	Experimental Brain Research
Volume	54
Issue number	2
DOIs	https://doi.org/10.1007/BF00236239
State	Published - Mar 1984

Keywords

Diethyl ether
Locus coeruleus
Raphe centralis
Tyrosine hydroxylase

ASJC Scopus subject areas

Neuroscience(all)

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10.1007/BF00236239

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AB - Variations in tyrosine hydroxylase (TH) activity and serotonin (5-HT) content in the rat locus coeruleus were measured four days after lesion of the nucleus raphe centralis superior. Lesions were made under either ether or pentobarbital anaesthesia and, in addition, (under ether) in rats pretreated with atropine or with lesions of the medial septum. Results showed a dissociation between 5-HT reduction and TH induction, differences due to the anaesthetic used, and a possible influence from limbic centres on 5-HT in the LC. These findings are discussed in terms of the apparent complexity of raphe-coerulean interactions.

KW - Diethyl ether

KW - Locus coeruleus

KW - Raphe centralis

KW - Tyrosine hydroxylase

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Anaesthetic and forebrain modulation of raphe-coerulean interactions

Abstract

Keywords

ASJC Scopus subject areas

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