An intramolecular passerini reaction: Synthesis of hydrastine.

J R Falck, Sukumar Manna

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


An intramolecular Passerini reaction between 3,4-methylenedioxyphenethylisocyanide and opianic acid is applied in a total synthesis of hydrastine, a phthalideisoquinoline alkaloid.

Original languageEnglish (US)
Pages (from-to)619-620
Number of pages2
JournalTetrahedron Letters
Issue number7
StatePublished - 1981

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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