An essential role in liver development for transcription factor XBP-1

Andreas M. Reimold; Amit Etkin; Isabelle Clauss; Andrew Perkins; Daniel S. Friend; John Zhang; Heidi F. Horton; Andrew Scott; Stuart H. Orkin; Michael C. Byrne; Michael J. Grusby; Laurie H. Glimcher

An essential role in liver development for transcription factor XBP-1

Andreas M. Reimold, Amit Etkin, Isabelle Clauss, Andrew Perkins, Daniel S. Friend, John Zhang, Heidi F. Horton, Andrew Scott, Stuart H. Orkin, Michael C. Byrne, Michael J. Grusby, Laurie H. Glimcher

Research output: Contribution to journal › Article › peer-review

462 Scopus citations

Abstract

XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target genes of XBP- 1 in the liver were identified as αFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members. Therefore, XBP-1 is a transcription factor essential for hepatocyte growth.

Original language	English (US)
Pages (from-to)	152-157
Number of pages	6
Journal	Genes and Development
Volume	14
Issue number	2
State	Published - Jan 15 2000

Keywords

Acute phase protein
Apoptosis
CREB/ATF family
Hepatocyte
Liver development
Transcription factors

ASJC Scopus subject areas

Genetics
Developmental Biology

Cite this

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title = "An essential role in liver development for transcription factor XBP-1",

abstract = "XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target genes of XBP- 1 in the liver were identified as αFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members. Therefore, XBP-1 is a transcription factor essential for hepatocyte growth.",

keywords = "Acute phase protein, Apoptosis, CREB/ATF family, Hepatocyte, Liver development, Transcription factors",

author = "Reimold, {Andreas M.} and Amit Etkin and Isabelle Clauss and Andrew Perkins and Friend, {Daniel S.} and John Zhang and Horton, {Heidi F.} and Andrew Scott and Orkin, {Stuart H.} and Byrne, {Michael C.} and Grusby, {Michael J.} and Glimcher, {Laurie H.}",

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T1 - An essential role in liver development for transcription factor XBP-1

AU - Reimold, Andreas M.

AU - Etkin, Amit

AU - Clauss, Isabelle

AU - Perkins, Andrew

AU - Friend, Daniel S.

AU - Zhang, John

AU - Horton, Heidi F.

AU - Scott, Andrew

AU - Orkin, Stuart H.

AU - Byrne, Michael C.

AU - Grusby, Michael J.

AU - Glimcher, Laurie H.

PY - 2000/1/15

Y1 - 2000/1/15

N2 - XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target genes of XBP- 1 in the liver were identified as αFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members. Therefore, XBP-1 is a transcription factor essential for hepatocyte growth.

AB - XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target genes of XBP- 1 in the liver were identified as αFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members. Therefore, XBP-1 is a transcription factor essential for hepatocyte growth.

KW - Acute phase protein

KW - Apoptosis

KW - CREB/ATF family

KW - Hepatocyte

KW - Liver development

KW - Transcription factors

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JF - Genes and Development

IS - 2

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An essential role in liver development for transcription factor XBP-1

Abstract

Keywords

ASJC Scopus subject areas

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