TY - JOUR
T1 - An emerging blueprint for apoptosis in Drosophila
AU - Abrams, John M.
N1 - Funding Information:
I thank Gabriel Nunez, N. Inohara and Xiodang Wang for helpful discussions. This work was supported by grants from the NIA/NIH (RO1 AG12466) and the NSF (MCB-9816841).
PY - 1999/11/1
Y1 - 1999/11/1
N2 - Apoptosis research demonstrates that, even though the multitude of regulatory circuits controlling programmed cell death might diverge, core elements of the 'apoptotic engine' are widely conserved. Therefore, studies in less complex model systems such as the nematode and the fly, should continue to have a profound impact on our understanding of the process. This review explores genes and molecules that control apoptosis in Drosophila. The death induces Reaper, Grim and Hid relay signals, possibly through IAPs (inhibitor of apoptosis proteins) and Dark (an Apaf-1/Ced-4 homologoue), to trigger caspase function. This animal model promises continued insights into the determinants of cell death in 'naturally occurring' and pathological contexts.
AB - Apoptosis research demonstrates that, even though the multitude of regulatory circuits controlling programmed cell death might diverge, core elements of the 'apoptotic engine' are widely conserved. Therefore, studies in less complex model systems such as the nematode and the fly, should continue to have a profound impact on our understanding of the process. This review explores genes and molecules that control apoptosis in Drosophila. The death induces Reaper, Grim and Hid relay signals, possibly through IAPs (inhibitor of apoptosis proteins) and Dark (an Apaf-1/Ced-4 homologoue), to trigger caspase function. This animal model promises continued insights into the determinants of cell death in 'naturally occurring' and pathological contexts.
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U2 - 10.1016/S0962-8924(99)01646-3
DO - 10.1016/S0962-8924(99)01646-3
M3 - Review article
C2 - 10511707
AN - SCOPUS:0033231936
SN - 0962-8924
VL - 9
SP - 435
EP - 440
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 11
ER -