An assessment by the statin intolerance panel: 2014 update

John R. Guyton, Harold E. Bays, Scott M Grundy, Terry A. Jacobson

Research output: Contribution to journalArticlepeer-review

132 Scopus citations


This article from the National Lipid Association Statin Intolerance Panel provides a framework for understanding statin intolerance and makes general recommendations for health professionals. For specific guidance on adverse events related to muscle, liver, cognition, and glucose metabolism, one should refer to the other reports of the Statin Safety Task Force for those topics. Although statin adverse effects rarely lead to permanent sequelae, symptomatic intolerance frequently hinders cardiovascular risk reduction by statins. We emphasize here the advisory role of the clinician helping each patient to make personal decisions on statin tolerability. We identify a pressing need for further research on statin intolerance and make suggestions for research design.

Original languageEnglish (US)
Pages (from-to)S72-S81
JournalJournal of Clinical Lipidology
Issue number3 SUPPL
StatePublished - 2014


  • Drug intolerance
  • Patient-centered medicine
  • Statin adverse effects
  • Statin safety
  • Statins

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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