Ampullary Adenocarcinoma, Version 1.2023

E. Gabriela Chiorean; Marco Del Chiaro; Margaret A. Tempero; Mokenge P. Malafa; Al B. Benson; Dana B. Cardin; Jared A. Christensen; Vincent Chung; Brian Czito; Mary Dillhoff; Timothy R. Donahue; Efrat Dotan; Christos Fountzilas; Evan S. Glazer; Jeffrey Hardacre; William G. Hawkins; Kelsey Klute; Andrew H. Ko; John W. Kunstman; Noelle LoConte; Andrew M. Lowy; Ashiq Masood; Cassadie Moravek; Eric K. Nakakura; Amol K. Narang; Lorenzo Nardo; Jorge Obando; Patricio M. Polanco; Sushanth Reddy; Marsha Reyngold; Courtney Scaife; Jeanne Shen; Mark J. Truty; Charles Vollmer; Robert A. Wolff; Brian M. Wolpin; Beth McCullough; Senem Lubin; Susan D. Darlow

doi:10.6004/jnccn.2023.0034

Ampullary Adenocarcinoma, Version 1.2023

E. Gabriela Chiorean, Marco Del Chiaro, Margaret A. Tempero, Mokenge P. Malafa, Al B. Benson, Dana B. Cardin, Jared A. Christensen, Vincent Chung, Brian Czito, Mary Dillhoff, Timothy R. Donahue, Efrat Dotan, Christos Fountzilas, Evan S. Glazer, Jeffrey Hardacre, William G. Hawkins, Kelsey Klute, Andrew H. Ko, John W. Kunstman, Noelle LoConteAndrew M. Lowy, Ashiq Masood, Cassadie Moravek, Eric K. Nakakura, Amol K. Narang, Lorenzo Nardo, Jorge Obando, Patricio M. Polanco, Sushanth Reddy, Marsha Reyngold, Courtney Scaife, Jeanne Shen, Mark J. Truty, Charles Vollmer, Robert A. Wolff, Brian M. Wolpin, Beth McCullough, Senem Lubin, Susan D. Darlow

Research output: Contribution to journal › Article › peer-review

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Abstract

Ampullary cancers refer to tumors originating from the ampulla of Vater (the ampulla, the intraduodenal portion of the bile duct, and the intraduodenal portion of the pancreatic duct), while periampullary cancers may arise from locations encompassing the head of the pancreas, distal bile duct, duodenum, or ampulla of Vater. Ampullary cancers are rare gastrointestinal malignancies, and prognosis varies greatly based on factors such as patient age, TNM classification, differentiation grade, and treatment modality received. Systemic therapy is used in all stages of ampullary cancer, including neoadjuvant therapy, adjuvant therapy, and first-line or subsequent-line therapy for locally advanced, metastatic, and recurrent disease. Radiation therapy may be used in localized ampullary cancer, sometimes in combination with chemotherapy, but there is no high-level evidence to support its utility. Select tumors may be treated surgically. This article describes NCCN recommendations regarding management of ampullary adenocarcinoma.

Original language	English (US)
Pages (from-to)	753-782
Number of pages	30
Journal	JNCCN Journal of the National Comprehensive Cancer Network
Volume	21
Issue number	7
DOIs	https://doi.org/10.6004/jnccn.2023.0034
State	Published - Jul 2023

ASJC Scopus subject areas

Oncology

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10.6004/jnccn.2023.0034

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Chiorean, E. G., Chiaro, M. D., Tempero, M. A., Malafa, M. P., Benson, A. B., Cardin, D. B., Christensen, J. A., Chung, V., Czito, B., Dillhoff, M., Donahue, T. R., Dotan, E., Fountzilas, C., Glazer, E. S., Hardacre, J., Hawkins, W. G., Klute, K., Ko, A. H., Kunstman, J. W., ... Darlow, S. D. (2023). Ampullary Adenocarcinoma, Version 1.2023. JNCCN Journal of the National Comprehensive Cancer Network, 21(7), 753-782. https://doi.org/10.6004/jnccn.2023.0034

Chiorean, EG, Chiaro, MD, Tempero, MA, Malafa, MP, Benson, AB, Cardin, DB, Christensen, JA, Chung, V, Czito, B, Dillhoff, M, Donahue, TR, Dotan, E, Fountzilas, C, Glazer, ES, Hardacre, J, Hawkins, WG, Klute, K, Ko, AH, Kunstman, JW, LoConte, N, Lowy, AM, Masood, A, Moravek, C, Nakakura, EK, Narang, AK, Nardo, L, Obando, J, Polanco, PM, Reddy, S, Reyngold, M, Scaife, C, Shen, J, Truty, MJ, Vollmer, C, Wolff, RA, Wolpin, BM, McCullough, B, Lubin, S & Darlow, SD 2023, 'Ampullary Adenocarcinoma, Version 1.2023', JNCCN Journal of the National Comprehensive Cancer Network, vol. 21, no. 7, pp. 753-782. https://doi.org/10.6004/jnccn.2023.0034

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title = "Ampullary Adenocarcinoma, Version 1.2023",

abstract = "Ampullary cancers refer to tumors originating from the ampulla of Vater (the ampulla, the intraduodenal portion of the bile duct, and the intraduodenal portion of the pancreatic duct), while periampullary cancers may arise from locations encompassing the head of the pancreas, distal bile duct, duodenum, or ampulla of Vater. Ampullary cancers are rare gastrointestinal malignancies, and prognosis varies greatly based on factors such as patient age, TNM classification, differentiation grade, and treatment modality received. Systemic therapy is used in all stages of ampullary cancer, including neoadjuvant therapy, adjuvant therapy, and first-line or subsequent-line therapy for locally advanced, metastatic, and recurrent disease. Radiation therapy may be used in localized ampullary cancer, sometimes in combination with chemotherapy, but there is no high-level evidence to support its utility. Select tumors may be treated surgically. This article describes NCCN recommendations regarding management of ampullary adenocarcinoma.",

author = "Chiorean, {E. Gabriela} and Chiaro, {Marco Del} and Tempero, {Margaret A.} and Malafa, {Mokenge P.} and Benson, {Al B.} and Cardin, {Dana B.} and Christensen, {Jared A.} and Vincent Chung and Brian Czito and Mary Dillhoff and Donahue, {Timothy R.} and Efrat Dotan and Christos Fountzilas and Glazer, {Evan S.} and Jeffrey Hardacre and Hawkins, {William G.} and Kelsey Klute and Ko, {Andrew H.} and Kunstman, {John W.} and Noelle LoConte and Lowy, {Andrew M.} and Ashiq Masood and Cassadie Moravek and Nakakura, {Eric K.} and Narang, {Amol K.} and Lorenzo Nardo and Jorge Obando and Polanco, {Patricio M.} and Sushanth Reddy and Marsha Reyngold and Courtney Scaife and Jeanne Shen and Truty, {Mark J.} and Charles Vollmer and Wolff, {Robert A.} and Wolpin, {Brian M.} and Beth McCullough and Senem Lubin and Darlow, {Susan D.}",

year = "2023",

month = jul,

doi = "10.6004/jnccn.2023.0034",

language = "English (US)",

volume = "21",

pages = "753--782",

journal = "JNCCN Journal of the National Comprehensive Cancer Network",

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T1 - Ampullary Adenocarcinoma, Version 1.2023

AU - Chiorean, E. Gabriela

AU - Chiaro, Marco Del

AU - Tempero, Margaret A.

AU - Malafa, Mokenge P.

AU - Benson, Al B.

AU - Cardin, Dana B.

AU - Christensen, Jared A.

AU - Chung, Vincent

AU - Czito, Brian

AU - Dillhoff, Mary

AU - Donahue, Timothy R.

AU - Dotan, Efrat

AU - Fountzilas, Christos

AU - Glazer, Evan S.

AU - Hardacre, Jeffrey

AU - Hawkins, William G.

AU - Klute, Kelsey

AU - Ko, Andrew H.

AU - Kunstman, John W.

AU - LoConte, Noelle

AU - Lowy, Andrew M.

AU - Masood, Ashiq

AU - Moravek, Cassadie

AU - Nakakura, Eric K.

AU - Narang, Amol K.

AU - Nardo, Lorenzo

AU - Obando, Jorge

AU - Polanco, Patricio M.

AU - Reddy, Sushanth

AU - Reyngold, Marsha

AU - Scaife, Courtney

AU - Shen, Jeanne

AU - Truty, Mark J.

AU - Vollmer, Charles

AU - Wolff, Robert A.

AU - Wolpin, Brian M.

AU - McCullough, Beth

AU - Lubin, Senem

AU - Darlow, Susan D.

PY - 2023/7

Y1 - 2023/7

N2 - Ampullary cancers refer to tumors originating from the ampulla of Vater (the ampulla, the intraduodenal portion of the bile duct, and the intraduodenal portion of the pancreatic duct), while periampullary cancers may arise from locations encompassing the head of the pancreas, distal bile duct, duodenum, or ampulla of Vater. Ampullary cancers are rare gastrointestinal malignancies, and prognosis varies greatly based on factors such as patient age, TNM classification, differentiation grade, and treatment modality received. Systemic therapy is used in all stages of ampullary cancer, including neoadjuvant therapy, adjuvant therapy, and first-line or subsequent-line therapy for locally advanced, metastatic, and recurrent disease. Radiation therapy may be used in localized ampullary cancer, sometimes in combination with chemotherapy, but there is no high-level evidence to support its utility. Select tumors may be treated surgically. This article describes NCCN recommendations regarding management of ampullary adenocarcinoma.

AB - Ampullary cancers refer to tumors originating from the ampulla of Vater (the ampulla, the intraduodenal portion of the bile duct, and the intraduodenal portion of the pancreatic duct), while periampullary cancers may arise from locations encompassing the head of the pancreas, distal bile duct, duodenum, or ampulla of Vater. Ampullary cancers are rare gastrointestinal malignancies, and prognosis varies greatly based on factors such as patient age, TNM classification, differentiation grade, and treatment modality received. Systemic therapy is used in all stages of ampullary cancer, including neoadjuvant therapy, adjuvant therapy, and first-line or subsequent-line therapy for locally advanced, metastatic, and recurrent disease. Radiation therapy may be used in localized ampullary cancer, sometimes in combination with chemotherapy, but there is no high-level evidence to support its utility. Select tumors may be treated surgically. This article describes NCCN recommendations regarding management of ampullary adenocarcinoma.

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M3 - Article

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AN - SCOPUS:85164383189

SN - 1540-1405

VL - 21

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EP - 782

JO - JNCCN Journal of the National Comprehensive Cancer Network

JF - JNCCN Journal of the National Comprehensive Cancer Network

IS - 7

ER -

Ampullary Adenocarcinoma, Version 1.2023

Abstract

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