Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage

Milan R. Savani; Kalil G. Abdullah; Samuel K. McBrayer

doi:10.1016/j.molcel.2020.07.014

Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage

Milan R. Savani, Kalil G. Abdullah, Samuel K. McBrayer

Research output: Contribution to journal › Article › peer-review

Abstract

A recent study (Sulkowski et al., 2020) reveals that oncometabolites, which are produced by metabolic gene mutations in many cancers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obscuring epigenetic marks that are necessary for efficient DNA repair.

Original language	English (US)
Pages (from-to)	368-370
Number of pages	3
Journal	Molecular cell
Volume	79
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2020.07.014
State	Published - Aug 6 2020

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2020.07.014

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title = "Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage",

abstract = "A recent study (Sulkowski et al., 2020) reveals that oncometabolites, which are produced by metabolic gene mutations in many cancers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obscuring epigenetic marks that are necessary for efficient DNA repair.",

author = "Savani, {Milan R.} and Abdullah, {Kalil G.} and McBrayer, {Samuel K.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

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day = "6",

doi = "10.1016/j.molcel.2020.07.014",

language = "English (US)",

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AU - Savani, Milan R.

AU - Abdullah, Kalil G.

AU - McBrayer, Samuel K.

PY - 2020/8/6

Y1 - 2020/8/6

N2 - A recent study (Sulkowski et al., 2020) reveals that oncometabolites, which are produced by metabolic gene mutations in many cancers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obscuring epigenetic marks that are necessary for efficient DNA repair.

AB - A recent study (Sulkowski et al., 2020) reveals that oncometabolites, which are produced by metabolic gene mutations in many cancers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obscuring epigenetic marks that are necessary for efficient DNA repair.

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Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage

Abstract

ASJC Scopus subject areas

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