TY - JOUR
T1 - Amino-Terminal Pro-B-Type Natriuretic Peptides
T2 - Testing in General Populations
AU - de Lemos, James A
AU - Hildebrandt, Per
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/2/4
Y1 - 2008/2/4
N2 - Screening of general populations with amino-terminal pro-B-type natriuretic peptides (NT-proBNP) holds promise for the detection of significant underlying cardiac structural and functional abnormalities, as well as for the early detection of the propensity to develop future cardiovascular events. In comparative studies to date, NT-proBNP performs at least as well as BNP in the detection of heart disease and prognostication in the general population. In some studies and subgroups, NT-proBNP appears to outperform BNP in population screening. More needs to be learned about noncardiac sources of NT-proBNP variation in "apparently well" populations. Better understanding of these factors may allow optimization of thresholds for screening of apparently well patients and concomitant delineation of patient populations in whom NT-proBNP screening is less appropriate.
AB - Screening of general populations with amino-terminal pro-B-type natriuretic peptides (NT-proBNP) holds promise for the detection of significant underlying cardiac structural and functional abnormalities, as well as for the early detection of the propensity to develop future cardiovascular events. In comparative studies to date, NT-proBNP performs at least as well as BNP in the detection of heart disease and prognostication in the general population. In some studies and subgroups, NT-proBNP appears to outperform BNP in population screening. More needs to be learned about noncardiac sources of NT-proBNP variation in "apparently well" populations. Better understanding of these factors may allow optimization of thresholds for screening of apparently well patients and concomitant delineation of patient populations in whom NT-proBNP screening is less appropriate.
UR - http://www.scopus.com/inward/record.url?scp=38649131778&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38649131778&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2007.11.014
DO - 10.1016/j.amjcard.2007.11.014
M3 - Article
C2 - 18243852
AN - SCOPUS:38649131778
SN - 0002-9149
VL - 101
SP - S16-S20
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 3 SUPPL.
ER -