TY - JOUR
T1 - Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss
AU - Geidenstam, Nina
AU - Magnusson, Martin
AU - Danielsson, Anders P.H.
AU - Gerszten, Robert E.
AU - Wang, Thomas J.
AU - Reinius, Lovisa E.
AU - Mulder, Hindrik
AU - Melander, Olle
AU - Ridderstråle, Martin
N1 - Funding Information:
This work was supported by the Swedish Research Council, the Novo Nordisk Foundation, Skåne Regional Council, ALF, the Albert Påhlsson Foundation, the Swedish Heart and Lung Foundation, the Medical Faculty of Lund University, Skåne University Hospital, the Ernhold Lundströms Research Foundation, the Hulda and Conrad Mossfelt Foundation, the Southwest Skåne Diabetes Foundation, the King Gustaf V and Queen Victoria Foundation, the Lennart Hanssons Memorial Fund, Knut and Alice Wallenberg Foundation, the Marianne and Marcus Wallenberg Foundation, and the Crafoord Foundation.
Publisher Copyright:
© 2017 Nina Geidenstam et al.
PY - 2017
Y1 - 2017
N2 - Aims. We investigated the relationship between circulating amino acid levels and obesity; to what extent weight loss followed by weight maintenance can correct amino acid abnormalities; and whether amino acids are related to weight loss. Methods. Amino acids associated with waist circumference (WC) and BMI were studied in 804 participants from the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC). Changes in amino acid levels were analyzed after weight loss and weight maintenance in 12 obese subjects and evaluated in a replication cohort (n=83). Results. Out of the eight identified BMI-associated amino acids from the MDC-CC, alanine, isoleucine, tyrosine, phenylalanine, and glutamate decreased after weight loss, while asparagine increased after weight maintenance. These changes were validated in the replication cohort. Scores that were constructed based on obesity-associated amino acids and known risk factors decreased in the ≥10% weight loss group with an associated change in BMI (R2=0.16-0.22, p<0.002), whereas the scores increased in the <10% weight loss group (p<0.0004). Conclusions. Weight loss followed by weight maintenance leads to differential changes in amino acid levels associated with obesity. Treatment modifiable scores based on epidemiological and interventional data may be used to evaluate the potential metabolic benefit of weight loss.
AB - Aims. We investigated the relationship between circulating amino acid levels and obesity; to what extent weight loss followed by weight maintenance can correct amino acid abnormalities; and whether amino acids are related to weight loss. Methods. Amino acids associated with waist circumference (WC) and BMI were studied in 804 participants from the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC). Changes in amino acid levels were analyzed after weight loss and weight maintenance in 12 obese subjects and evaluated in a replication cohort (n=83). Results. Out of the eight identified BMI-associated amino acids from the MDC-CC, alanine, isoleucine, tyrosine, phenylalanine, and glutamate decreased after weight loss, while asparagine increased after weight maintenance. These changes were validated in the replication cohort. Scores that were constructed based on obesity-associated amino acids and known risk factors decreased in the ≥10% weight loss group with an associated change in BMI (R2=0.16-0.22, p<0.002), whereas the scores increased in the <10% weight loss group (p<0.0004). Conclusions. Weight loss followed by weight maintenance leads to differential changes in amino acid levels associated with obesity. Treatment modifiable scores based on epidemiological and interventional data may be used to evaluate the potential metabolic benefit of weight loss.
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U2 - 10.1155/2017/6490473
DO - 10.1155/2017/6490473
M3 - Article
C2 - 28484491
AN - SCOPUS:85018993935
SN - 1687-8337
VL - 2017
JO - International Journal of Endocrinology
JF - International Journal of Endocrinology
M1 - 6490473
ER -