Amino Acid Sensing: Architecture of mTORC1 on the Lysosome Surface

Wei Peng; Jenna L. Jewell

doi:10.1016/j.cub.2019.11.087

Amino Acid Sensing: Architecture of mTORC1 on the Lysosome Surface

Wei Peng, Jenna L. Jewell

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Amino acid signaling through the Rag GTPases promotes mTORC1 lysosomal localization and subsequent activation. Two new cryo-EM structures examine the architecture of the Rag GTPase heterodimers complexed with mTORC1. Amino acid signaling through the Rag GTPases promotes mTORC1 lysosomal localization and subsequent activation. Two new cryo-EM structures examine the architecture of the Rag GTPase heterodimers complexed with mTORC1.

Original language	English (US)
Pages (from-to)	R89-R91
Journal	Current Biology
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/j.cub.2019.11.087
State	Published - Jan 20 2020

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

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title = "Amino Acid Sensing: Architecture of mTORC1 on the Lysosome Surface",

abstract = "Amino acid signaling through the Rag GTPases promotes mTORC1 lysosomal localization and subsequent activation. Two new cryo-EM structures examine the architecture of the Rag GTPase heterodimers complexed with mTORC1. Amino acid signaling through the Rag GTPases promotes mTORC1 lysosomal localization and subsequent activation. Two new cryo-EM structures examine the architecture of the Rag GTPase heterodimers complexed with mTORC1.",

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Amino Acid Sensing: Architecture of mTORC1 on the Lysosome Surface

Abstract

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