TY - JOUR
T1 - Alterations in the hemodynamic response function in cognitively impaired HIV/AIDS subjects
AU - Juengst, Shannon B.
AU - Aizenstein, Howard J.
AU - Figurski, Jennifer
AU - Lopez, Oscar L.
AU - Becker, James T.
N1 - Funding Information:
This research was supported in part by funds from the National Institute on Aging to J.T.B. (AG21431). H.J.A. was the recipient of a K-23 Award from the National Institute of Mental Health (MH64678).
PY - 2007/7/30
Y1 - 2007/7/30
N2 - Functional magnetic resonance imaging (fMRI) has revealed much about altered CNS function in HIV/AIDS. In this study, we compared the blood oxygen level dependent hemodynamic response function (BOLD HRF) signal in HIV/AIDS and control subjects as a necessary pre-condition for fMRI studies of higher level cognitive function. Using event-related fMRI, subjects performed a simple sensory-motor activity allowing the measurement of the BOLD HRF in the precentral gyrus. There were no significant differences in the HRF when viewed as a function of age, hemisphere, or HIV serostatus. However, significant results were found after dividing the subjects by NIMH impairment classifications. There were 16 control subjects, 19 Normal/Asymptomatic Neuropsychological Impairment (ANI), and 11 Minor Neurocognitive Disorder (MNCD)/HIV-Associated Dementia (HAD) subjects. The HRF of MNCD/HAD subjects did not return to baseline after 16 s, suggesting subtle alterations in neuronal function, which may affect event-related fMRI studies.
AB - Functional magnetic resonance imaging (fMRI) has revealed much about altered CNS function in HIV/AIDS. In this study, we compared the blood oxygen level dependent hemodynamic response function (BOLD HRF) signal in HIV/AIDS and control subjects as a necessary pre-condition for fMRI studies of higher level cognitive function. Using event-related fMRI, subjects performed a simple sensory-motor activity allowing the measurement of the BOLD HRF in the precentral gyrus. There were no significant differences in the HRF when viewed as a function of age, hemisphere, or HIV serostatus. However, significant results were found after dividing the subjects by NIMH impairment classifications. There were 16 control subjects, 19 Normal/Asymptomatic Neuropsychological Impairment (ANI), and 11 Minor Neurocognitive Disorder (MNCD)/HIV-Associated Dementia (HAD) subjects. The HRF of MNCD/HAD subjects did not return to baseline after 16 s, suggesting subtle alterations in neuronal function, which may affect event-related fMRI studies.
KW - Aging
KW - BOLD response
KW - Cognitive impairment
KW - HIV
KW - Hemodynamic response function
KW - Neuropsychological impairment
KW - fMRI
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U2 - 10.1016/j.jneumeth.2007.03.004
DO - 10.1016/j.jneumeth.2007.03.004
M3 - Article
C2 - 17540453
AN - SCOPUS:34249893890
SN - 0165-0270
VL - 163
SP - 208
EP - 212
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
IS - 2
ER -