TY - JOUR
T1 - Alterations in resting functional connectivity due to recent motor task
AU - Tung, Kuang Chi
AU - Uh, Jinsoo
AU - Mao, Deng
AU - Xu, Feng
AU - Xiao, Guanghua
AU - Lu, Hanzhang
N1 - Funding Information:
This study was supported in part by NIH grants R01 MH084021 (to HL), R01 NS067015 (to HL), R01 AG042753 (to HL), R21 NS078656 (to HL), and R21 AG034318 (to HL). The authors are grateful to Dr. Janet Jerrow for scientific editing of the manuscript.
PY - 2013/9
Y1 - 2013/9
N2 - The impact of recent experiences of task performance on resting functional connectivity MRI (fcMRI) has important implications for the design of many neuroimaging studies, because, if an effect is present, the fcMRI scan then must be performed before any evoked fMRI or after a time gap to allow it to dissipate. The present study aims to determine the effect of simple button presses, which are used in many cognitive fMRI tasks as a response recording method, on later acquired fcMRI data. Human volunteers were subject to a 23-minute button press motor task. Their resting-state brain activity before and after the task was assessed with fcMRI. It was found that, compared to the pre-task resting period, the post-task resting fcMRI revealed a significantly higher (p. =. 0.002, N. =. 24) cross correlation coefficient (CC) between left and right motor cortices. These changes were not present in sham control studies that matched the paradigm timing but had no actual task. The amplitude of fcMRI signal fluctuation (AF) also demonstrated an increase in the post-task period compared to pre-task. These changes were observed using both the right-hand-only task and the two-hand task. Study of the recovery time course of these effects revealed that the CC changes lasted for about 5. min while the AF change lasted for at least 15. min. Finally, voxelwise analysis revealed that the pre/post-task differences were also observed in several other brain regions, including the auditory cortex, visual areas, and the thalamus. Our data suggest that the recent performance of the simple button press task can result in elevated fcMRI CC and AF in relevant brain networks and that fcMRI scan should be performed either before evoked fMRI or after a sufficient time gap following fMRI.
AB - The impact of recent experiences of task performance on resting functional connectivity MRI (fcMRI) has important implications for the design of many neuroimaging studies, because, if an effect is present, the fcMRI scan then must be performed before any evoked fMRI or after a time gap to allow it to dissipate. The present study aims to determine the effect of simple button presses, which are used in many cognitive fMRI tasks as a response recording method, on later acquired fcMRI data. Human volunteers were subject to a 23-minute button press motor task. Their resting-state brain activity before and after the task was assessed with fcMRI. It was found that, compared to the pre-task resting period, the post-task resting fcMRI revealed a significantly higher (p. =. 0.002, N. =. 24) cross correlation coefficient (CC) between left and right motor cortices. These changes were not present in sham control studies that matched the paradigm timing but had no actual task. The amplitude of fcMRI signal fluctuation (AF) also demonstrated an increase in the post-task period compared to pre-task. These changes were observed using both the right-hand-only task and the two-hand task. Study of the recovery time course of these effects revealed that the CC changes lasted for about 5. min while the AF change lasted for at least 15. min. Finally, voxelwise analysis revealed that the pre/post-task differences were also observed in several other brain regions, including the auditory cortex, visual areas, and the thalamus. Our data suggest that the recent performance of the simple button press task can result in elevated fcMRI CC and AF in relevant brain networks and that fcMRI scan should be performed either before evoked fMRI or after a sufficient time gap following fMRI.
KW - Blood oxygenation
KW - Functional connectivity MRI
KW - Motor cortex
KW - Resting state
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U2 - 10.1016/j.neuroimage.2013.04.006
DO - 10.1016/j.neuroimage.2013.04.006
M3 - Article
C2 - 23583747
AN - SCOPUS:84877331544
SN - 1053-8119
VL - 78
SP - 316
EP - 324
JO - NeuroImage
JF - NeuroImage
ER -