TY - JOUR
T1 - Alloimmune Neutropenia in a Neonate
T2 - Case Report and Review of Literature
AU - Prasath, Arun
AU - Grafius, Alanna
AU - Bonanno, Mona
AU - Ambrusko, Steven
AU - Nair, Jayasree
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/12
Y1 - 2022/12
N2 - Neonatal alloimmune neutropenia, variably referred to in the literature as NAIN, FNAIN or NIN, is a disorder of neutrophil destruction in newborns similar to better-known conditions such as hemolytic disease of the newborn and neonatal alloimmune thrombocytopenia (FNAIT). Infants affected by this self-limiting condition can present asymptomatically or have a wide range of symptoms, from skin manifestations and mucositis to severe infections such as sepsis and pneumonia. In our case, we report an otherwise asymptomatic term infant born with severe neutropenia to a mother affected by COVID-19 in the 3rd trimester. However, it is unclear if COVID-19 contributed to our patients’ neutropenia. Diagnostic testing eventually revealed the presence of anti-neutrophil antibodies, confirming the diagnosis of alloimmune neutropenia. The infant was conservatively managed with early discharge prior to resolution of neutropenia and close post-discharge follow up.
AB - Neonatal alloimmune neutropenia, variably referred to in the literature as NAIN, FNAIN or NIN, is a disorder of neutrophil destruction in newborns similar to better-known conditions such as hemolytic disease of the newborn and neonatal alloimmune thrombocytopenia (FNAIT). Infants affected by this self-limiting condition can present asymptomatically or have a wide range of symptoms, from skin manifestations and mucositis to severe infections such as sepsis and pneumonia. In our case, we report an otherwise asymptomatic term infant born with severe neutropenia to a mother affected by COVID-19 in the 3rd trimester. However, it is unclear if COVID-19 contributed to our patients’ neutropenia. Diagnostic testing eventually revealed the presence of anti-neutrophil antibodies, confirming the diagnosis of alloimmune neutropenia. The infant was conservatively managed with early discharge prior to resolution of neutropenia and close post-discharge follow up.
KW - alloimmune neutropenia
KW - anti-neutrophil antibodies
KW - neonatal neutropenia
UR - http://www.scopus.com/inward/record.url?scp=85144369784&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85144369784&partnerID=8YFLogxK
U2 - 10.3390/antib11040063
DO - 10.3390/antib11040063
M3 - Article
C2 - 36278616
AN - SCOPUS:85144369784
SN - 2073-4468
VL - 11
JO - Antibodies
JF - Antibodies
IS - 4
M1 - 63
ER -