Allergic fungal sinusitis

Richard L. Mabry, Bradley F. Marple

Research output: Contribution to journalReview articlepeer-review


Allergic fungal sinusitis is a challenging problem. It probably results from entrapment of fungal forms in the sinuses of patients with associated atopy. The characteristic clinical picture is pansinusitis (unilateral more than bilateral) and polyposis, recurrent despite previous surgeries. Radiographic studies present a characteristic pattern. At surgery, in addition to polyps and pansinusitis, the most distinctive finding is allergic mucin. This tenaceous, dark, rubbery material contains numerous eosinophils and Charcot-Leyden crystals, and fungal stains show the presence of noninvasive hyphae. Fungal cultures may or may not be positive. The differential diagnosis of allergic fungal sinusitis includes allergic mucin sinusitis, mycetoma, or saprophytic fungal growth within a diseased sinus. Treatment involves adequate surgical exenteration, the use of corticosteroids (topical and systemic), and postoperative cleaning. Despite warnings to the contrary, immunotherapy with fungal antigens may be of significant benefit.

Original languageEnglish (US)
Pages (from-to)49-52
Number of pages4
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Issue number1
StatePublished - Apr 16 1997

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


Dive into the research topics of 'Allergic fungal sinusitis'. Together they form a unique fingerprint.

Cite this