Albumin decreases hydrogen peroxide and reperfusion injury in isolated rat hearts

James M. Brown, Connie J. Beehler, Elaine M. Berger, Michael A. Grosso, Glenn J. Whitman, Lance S. Terada, John A. Leff, Alden H. Harken, John E. Repine

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Perfusion with human serum albumin decreased myocardial hydrogen peroxide (H2O2) levels (as assessed by inactivation of myocardial catalase activities following ammotriazole pretreatment) and increased myocardial ventricular developed pressures (DP), contractility (+dP/dt) but not relaxation rate (-dP/dt) in isolated crystalloid perfused rat hearts subjected to normothermic global ischemia (20 min) and then reperfusion (40 min). Albumin also decreased H2O2 concentrations in vitro. The findings support the possibility that albumin may act as a protective O2 metabolite scavenger in vivo.

Original languageEnglish (US)
Pages (from-to)583-589
Number of pages7
Issue number5
StatePublished - Oct 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Albumin decreases hydrogen peroxide and reperfusion injury in isolated rat hearts'. Together they form a unique fingerprint.

Cite this