Aging mechanisims

Yoshiko Takahashi, Makoto Kuro-O, Fuyuki Ishikawa

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Aging (senescence) has long been a difficult issue to be experimentally analyzed because of stochastic processes, which contrast with the programmed events during early development. However, we have recently started to learn the molecular mechanisms that control aging. Studies of the mutant mouse, klotho, showing premature aging, raise a possibility that mammals have an 'anti-aging hormone.' A decrease of cell proliferation ability caused by the telomeres is also tightly linked to senescence. Frontier experimental studies of aging at the molecular level are leading to fascinating hypotheses that aging is the price we had to pay for the evolution of the sexual reproduction system that produces a variety of genetic information and complex body structures.

Original languageEnglish (US)
Pages (from-to)12407-12408
Number of pages2
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number23
StatePublished - 2000

ASJC Scopus subject areas

  • General


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