TY - JOUR
T1 - Aging mechanisims
AU - Takahashi, Yoshiko
AU - Kuro-O, Makoto
AU - Ishikawa, Fuyuki
PY - 2000
Y1 - 2000
N2 - Aging (senescence) has long been a difficult issue to be experimentally analyzed because of stochastic processes, which contrast with the programmed events during early development. However, we have recently started to learn the molecular mechanisms that control aging. Studies of the mutant mouse, klotho, showing premature aging, raise a possibility that mammals have an 'anti-aging hormone.' A decrease of cell proliferation ability caused by the telomeres is also tightly linked to senescence. Frontier experimental studies of aging at the molecular level are leading to fascinating hypotheses that aging is the price we had to pay for the evolution of the sexual reproduction system that produces a variety of genetic information and complex body structures.
AB - Aging (senescence) has long been a difficult issue to be experimentally analyzed because of stochastic processes, which contrast with the programmed events during early development. However, we have recently started to learn the molecular mechanisms that control aging. Studies of the mutant mouse, klotho, showing premature aging, raise a possibility that mammals have an 'anti-aging hormone.' A decrease of cell proliferation ability caused by the telomeres is also tightly linked to senescence. Frontier experimental studies of aging at the molecular level are leading to fascinating hypotheses that aging is the price we had to pay for the evolution of the sexual reproduction system that produces a variety of genetic information and complex body structures.
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U2 - 10.1073/pnas.210382097
DO - 10.1073/pnas.210382097
M3 - Article
C2 - 11035783
AN - SCOPUS:0034619336
SN - 0027-8424
VL - 97
SP - 12407
EP - 12408
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 23
ER -