Aging and Heart Failure With Preserved Ejection Fraction

James P. MacNamara; Satyam Sarma; Benjamin D. Levine

doi:10.1016/B978-0-323-64067-1.00031-0

Aging and Heart Failure With Preserved Ejection Fraction

James P. MacNamara, Satyam Sarma, Benjamin D. Levine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Heart failure with preserved ejection fraction (HFpEF) occurs commonly in the elderly and carries a high risk for morbidity and mortality. The combination of expected changes with aging and pathologic changes associated with comorbidities, such as metabolic syndrome, lead to HFpEF. Aging results in slowing of left ventricular (LV) relaxation, and sedentary aging results in increased LV stiffness. Current echocardiographic markers struggle to differentiate age-related effects from so-called diastolic dysfunction, and care should be taken applying guideline cutoffs to the elderly. Finally, exercise training has potential to reverse the effects of sedentary aging on LV diastolic stiffness and may be an effective tool to prevent HFpEF.

Original language	English (US)
Title of host publication	Diastology
Subtitle of host publication	Clinical Approach to Heart Failure with Preserved Ejection Fraction
Publisher	Elsevier
Pages	425-441
Number of pages	17
ISBN (Electronic)	9780323640671
DOIs	https://doi.org/10.1016/B978-0-323-64067-1.00031-0
State	Published - Jan 1 2020

Keywords

Aging
Compliance
Diastolic function
Exercise
Heart failure with preserved ejection fraction
Physical activity
Relaxation

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-323-64067-1.00031-0

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abstract = "Heart failure with preserved ejection fraction (HFpEF) occurs commonly in the elderly and carries a high risk for morbidity and mortality. The combination of expected changes with aging and pathologic changes associated with comorbidities, such as metabolic syndrome, lead to HFpEF. Aging results in slowing of left ventricular (LV) relaxation, and sedentary aging results in increased LV stiffness. Current echocardiographic markers struggle to differentiate age-related effects from so-called diastolic dysfunction, and care should be taken applying guideline cutoffs to the elderly. Finally, exercise training has potential to reverse the effects of sedentary aging on LV diastolic stiffness and may be an effective tool to prevent HFpEF.",

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N2 - Heart failure with preserved ejection fraction (HFpEF) occurs commonly in the elderly and carries a high risk for morbidity and mortality. The combination of expected changes with aging and pathologic changes associated with comorbidities, such as metabolic syndrome, lead to HFpEF. Aging results in slowing of left ventricular (LV) relaxation, and sedentary aging results in increased LV stiffness. Current echocardiographic markers struggle to differentiate age-related effects from so-called diastolic dysfunction, and care should be taken applying guideline cutoffs to the elderly. Finally, exercise training has potential to reverse the effects of sedentary aging on LV diastolic stiffness and may be an effective tool to prevent HFpEF.

AB - Heart failure with preserved ejection fraction (HFpEF) occurs commonly in the elderly and carries a high risk for morbidity and mortality. The combination of expected changes with aging and pathologic changes associated with comorbidities, such as metabolic syndrome, lead to HFpEF. Aging results in slowing of left ventricular (LV) relaxation, and sedentary aging results in increased LV stiffness. Current echocardiographic markers struggle to differentiate age-related effects from so-called diastolic dysfunction, and care should be taken applying guideline cutoffs to the elderly. Finally, exercise training has potential to reverse the effects of sedentary aging on LV diastolic stiffness and may be an effective tool to prevent HFpEF.

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KW - Physical activity

KW - Relaxation

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ER -

Aging and Heart Failure With Preserved Ejection Fraction

Abstract

Keywords

ASJC Scopus subject areas

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