Aggressively recurring cervical intramedullary anaplastic astrocytoma in a pregnant patient

James P. Caruso, Chen Shi, Benjamin Rail, Salah G. Aoun, Carlos A. Bagley

Research output: Contribution to journalArticlepeer-review


Background: Many patients with spinal juvenile pilocytic astrocytoma can experience prolonged remission after resection. However, some reports suggest that pregnancy may be associated with progression. Case Description: The authors provide an image report highlighting a case of rapid and aggressive transformation of an intramedullary astrocytoma of the cervical spine in a pregnant patient. Over the course of 1 year, the lesion progressed from a juvenile pilocytic astrocytoma to an anaplastic astrocytoma. Genetic testing revealed mutations associated with aggressive behavior. Conclusion: The case and associated imaging demonstrate the importance of close neurologic monitoring and counseling regarding risk of progression in pregnant patients with spinal gliomas.

Original languageEnglish (US)
Article number466
JournalSurgical Neurology International
StatePublished - 2021


  • Anaplastic astrocytoma
  • FGFR1
  • Intramedullary
  • Pilocytic astrocytoma
  • SETD2
  • TACC1

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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