TY - JOUR
T1 - Aerosolized pentamidine for the prevention of Pneumocystis carinii pneumonia in children with cancer intolerant or allergic to trimethoprim/sulfamethoxazole
AU - Mustafa, Mahmoud M.
AU - Pappo, Alberto
AU - Cash, Jayne
AU - Winick, Naomi J.
AU - Buchanan, George R.
PY - 1994/2
Y1 - 1994/2
N2 - Purpose: Trimethoprim/sulfamethoxazole (TMP/SMX) is the drug of choice for Pneumocystis carinii pneumonia (PCP) prophylaxis in immunocompromised patients. In children with malignancy, TMP/SMX is well tolerated, but adverse reactions that necessitate discontinuation can occur. We evaluated the safety and efficacy of aerosolized pentamidine (AP) as an alternative prophylaxis modality in children with malignancy who are intolerant of or allergic to TMP/SMX. Patients and Methods: AP (200 mg/m2 every 4 weeks) was administered to 60 children with malignancy receiving chemotherapy who had experienced severe adverse reactions to TMP/SMX. Seven hundred twenty doses of AP have been administered during a 3 1/2 -year period (21,600 patient-days), with 30 patients treated for ≥ 12 months (range, 12 to 25). Results: Adverse reactions occurred during 79 (10%) of the 720 treatments and included bronchospasm in 23, cough in 40, vomiting in 10, and nausea in six. Only two patients had severe bronchospasm. AP was discontinued due to toxicity in three patients (5%). None of the patients (upper 95% confidence limit, 0.049) have developed PCP. Conclusion: AP appears to be well tolerated and effective in the prevention of PCP in children with malignancy.
AB - Purpose: Trimethoprim/sulfamethoxazole (TMP/SMX) is the drug of choice for Pneumocystis carinii pneumonia (PCP) prophylaxis in immunocompromised patients. In children with malignancy, TMP/SMX is well tolerated, but adverse reactions that necessitate discontinuation can occur. We evaluated the safety and efficacy of aerosolized pentamidine (AP) as an alternative prophylaxis modality in children with malignancy who are intolerant of or allergic to TMP/SMX. Patients and Methods: AP (200 mg/m2 every 4 weeks) was administered to 60 children with malignancy receiving chemotherapy who had experienced severe adverse reactions to TMP/SMX. Seven hundred twenty doses of AP have been administered during a 3 1/2 -year period (21,600 patient-days), with 30 patients treated for ≥ 12 months (range, 12 to 25). Results: Adverse reactions occurred during 79 (10%) of the 720 treatments and included bronchospasm in 23, cough in 40, vomiting in 10, and nausea in six. Only two patients had severe bronchospasm. AP was discontinued due to toxicity in three patients (5%). None of the patients (upper 95% confidence limit, 0.049) have developed PCP. Conclusion: AP appears to be well tolerated and effective in the prevention of PCP in children with malignancy.
UR - http://www.scopus.com/inward/record.url?scp=0028012494&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028012494&partnerID=8YFLogxK
U2 - 10.1200/JCO.1994.12.2.258
DO - 10.1200/JCO.1994.12.2.258
M3 - Article
C2 - 8113834
AN - SCOPUS:0028012494
SN - 0732-183X
VL - 12
SP - 258
EP - 261
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 2
ER -