TY - JOUR
T1 - Advances in functional neuroanatomy
T2 - A review of combined DTI and fMRI studies in healthy younger and older adults
AU - Bennett, Ilana J.
AU - Rypma, Bart
N1 - Funding Information:
This work was supported by grants from the National Institutes of Health/National Institute on Aging R01 AG029523 (B.R.) and F32 AG029523 (I.J.B.). The authors thank David J. Madden and Edward J. Golob for their comments on earlier drafts of this review.
PY - 2013/8
Y1 - 2013/8
N2 - Structural connections between brain regions are thought to influence neural processing within those regions. It follows that alterations to the quality of structural connections should influence the magnitude of neural activity. The quality of structural connections may also be expected to differentially influence activity in directly versus indirectly connected brain regions. To test these predictions, we reviewed studies that combined diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) in younger and older adults. By surveying studies that examined relationships between DTI measures of white matter integrity and fMRI measures of neural activity, we identified variables that accounted for variability in these relationships. Results revealed that relationships between white matter integrity and neural activity varied with (1) aging (i.e., positive and negative DTI-fMRI relationships in younger and older adults, respectively) and (2) spatial proximity of the neural measures (i.e., positive and negative DTI-fMRI relationships when neural measures were extracted from adjacent and non-adjacent brain regions, respectively). Together, the studies reviewed here provided support for both of our predictions.
AB - Structural connections between brain regions are thought to influence neural processing within those regions. It follows that alterations to the quality of structural connections should influence the magnitude of neural activity. The quality of structural connections may also be expected to differentially influence activity in directly versus indirectly connected brain regions. To test these predictions, we reviewed studies that combined diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) in younger and older adults. By surveying studies that examined relationships between DTI measures of white matter integrity and fMRI measures of neural activity, we identified variables that accounted for variability in these relationships. Results revealed that relationships between white matter integrity and neural activity varied with (1) aging (i.e., positive and negative DTI-fMRI relationships in younger and older adults, respectively) and (2) spatial proximity of the neural measures (i.e., positive and negative DTI-fMRI relationships when neural measures were extracted from adjacent and non-adjacent brain regions, respectively). Together, the studies reviewed here provided support for both of our predictions.
KW - Aging
KW - Diffusion tensor imaging, DTI
KW - Functional magnetic resonance imaging, fMRI
KW - Multimodal imaging
KW - Neurocognitive aging
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U2 - 10.1016/j.neubiorev.2013.04.008
DO - 10.1016/j.neubiorev.2013.04.008
M3 - Review article
C2 - 23628742
AN - SCOPUS:84878856807
SN - 0149-7634
VL - 37
SP - 1201
EP - 1210
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
IS - 7
ER -