@article{b0bb73f95fb34d2c85346ede7c9236f0,
title = "Adult haematopoietic stem cell niches",
abstract = "Stem cell niches are specialized microenvironments that promote the maintenance of stem cells and regulate their function. Recent advances have improved our understanding of the niches that maintain adult haematopoietic stem cells (HSCs). These advances include new markers for HSCs and niche cells, systematic analyses of the expression patterns of niche factors, genetic tools for functionally identifying niche cells in vivo, and improved imaging techniques. Together, they have shown that HSC niches are perivascular in the bone marrow and spleen. Endothelial cells and mesenchymal stromal cells secrete factors that promote HSC maintenance in these niches, but other cell types also directly or indirectly regulate HSC niches.",
author = "Crane, {Genevieve M.} and Elise Jeffery and Morrison, {Sean J.}",
note = "Funding Information: The authors apologize to those whose work could not be included owing to space limitations. S.J.M. is a Howard Hughes Medical Institute Investigator; the Mary McDermott Cook Chair in Pediatric Genetics; the Kathryne and Gene Bishop Distinguished Chair in Pediatric Research; and the Director of the Hamon Laboratory for Stem Cells and Cancer at the University of Texas Southwestern Medical Center, USA. G.M.C. was supported by the University of Texas Southwestern Medical Center Physician Scientist Training Program. E.J. is a postdoctoral fellow of the Damon Runyon Cancer Research Foundation. This work was supported by the Cancer Prevention and Research Institute of Texas, USA, and by the US National Institutes of Health (grants R37 AG024945 and R01 DK100848). Publisher Copyright: {\textcopyright}2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.",
year = "2017",
month = sep,
day = "1",
doi = "10.1038/nri.2017.53",
language = "English (US)",
volume = "17",
pages = "573--590",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "9",
}