ADMET evaluation in drug discovery. 11. PharmacoKinetics Knowledge Base (PKKB): A comprehensive database of pharmacokinetic and toxic properties for drugs

Engineering & Materials Science

• Pharmacokinetics 100%
• Drug Discovery 94%
• Metabolism 89%
• Toxicity 83%
• Biological Availability 25%
• Solubility 17%
• Blood 14%
• Plasmas 14%
• Glycoproteins 13%
• Protein Binding 12%
• Rats 9%
• Water 8%
• Brain 6%
• Information systems 6%

Chemical Compounds

• Pharmacological Metabolism 54%
• Pharmacokinetics 53%
• Toxic 53%
• Drug 37%
• Octanol-Water Partition Coefficient 20%
• Bioavailability 15%
• Glycoprotein P Inhibitor 12%
• Permeability 12%
• Lethal Dose 11%
• Vd 11%
• Solubility 9%
• Pharmacological Property 9%
• Clearance 8%
• Reaction Half Life 7%
• Dissociation Constant 7%
• Plasma 4%
• Protein 3%

Social Sciences

• drug 47%
• evaluation 32%
• permeability 20%
• water 12%
• information system 6%
• brain 6%
• electronics 5%