TY - JOUR
T1 - Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes
AU - Hsu, Fang Chi
AU - Yuan, Mingxia
AU - Bowden, Donald W.
AU - Xu, Jianzhao
AU - Smith, S. Carrie
AU - Wagenknecht, Lynne E.
AU - Langefeld, Carl D.
AU - Divers, Jasmin
AU - Register, Thomas C.
AU - Carr, J. Jeffrey
AU - Williamson, Jeff D.
AU - Sink, Kaycee M.
AU - Maldjian, Joseph A
AU - Freedman, Barry I.
N1 - Funding Information:
Grant support included General Clinical Research Center of Wake Forest School of Medicine M01 RR07122 ; National Institute of Neurological Disorders and Stroke R01 NS075107 (BIF) and R01 NS058700 (DWB); National Institute of Diabetes and Digestive and Kidney Diseases R01 DK071891 (BIF), and National Natural Science Foundation of China ( 81370946 ). Data expressed as mean (SD) for continuous characteristics; n (%) for discrete characteristics; median (min–max) for variables with skewed distributions. CVD: cardiovascular disease; COWA: Controlled Oral Word Association; CES-D: Center for Epidemiologic Studies-Depression.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Aims To assess associations between body mass index (BMI), waist circumference (WC), and computed tomography-determined volumes of pericardial, visceral, and subcutaneous adipose tissue with magnetic resonance imaging-(MRI) based cerebral structure and cognitive performance in individuals with type 2 diabetes (T2D). Methods This study was performed in 348 African Americans (AAs) and 256 European Americans (EAs) with T2D. Associations between adiposity measures with cerebral volumes of white matter (WMV), gray matter (GMV), white matter lesions, hippocampal GMV, and hippocampal WMV, cognitive performance and depression were examined using marginal models incorporating generalized estimating equations. All models were adjusted for age, sex, education, smoking, HbA1c, hypertension, statins, cardiovascular disease, MRI scanner (MRI outcomes only), and time between scans; some neuroimaging measures were additionally adjusted for intracranial volume. Results Participants were 59.9% female with mean (SD) age 57.7(9.3) years, diabetes duration 9.6(6.8) years, and HbA1c 7.8(1.9)%. In AAs, inverse associations were detected between hippocampal GMV and both BMI (β [95% CI] − 0.18 [− 0.30, − 0.07], P = 0.0018) and WC (− 0.23 [− 0.35, − 0.12], P = 0.0001). In the full bi-ethnic sample, inverse associations were detected between hippocampal WMV and WC (P ≤ 0.0001). Positive relationships were observed between BMI (P = 0.0007) and WC (P < 0.0001) with depression in EAs. Conclusions In patients with T2D, adiposity is inversely associated with hippocampal gray and white matter volumes.
AB - Aims To assess associations between body mass index (BMI), waist circumference (WC), and computed tomography-determined volumes of pericardial, visceral, and subcutaneous adipose tissue with magnetic resonance imaging-(MRI) based cerebral structure and cognitive performance in individuals with type 2 diabetes (T2D). Methods This study was performed in 348 African Americans (AAs) and 256 European Americans (EAs) with T2D. Associations between adiposity measures with cerebral volumes of white matter (WMV), gray matter (GMV), white matter lesions, hippocampal GMV, and hippocampal WMV, cognitive performance and depression were examined using marginal models incorporating generalized estimating equations. All models were adjusted for age, sex, education, smoking, HbA1c, hypertension, statins, cardiovascular disease, MRI scanner (MRI outcomes only), and time between scans; some neuroimaging measures were additionally adjusted for intracranial volume. Results Participants were 59.9% female with mean (SD) age 57.7(9.3) years, diabetes duration 9.6(6.8) years, and HbA1c 7.8(1.9)%. In AAs, inverse associations were detected between hippocampal GMV and both BMI (β [95% CI] − 0.18 [− 0.30, − 0.07], P = 0.0018) and WC (− 0.23 [− 0.35, − 0.12], P = 0.0001). In the full bi-ethnic sample, inverse associations were detected between hippocampal WMV and WC (P ≤ 0.0001). Positive relationships were observed between BMI (P = 0.0007) and WC (P < 0.0001) with depression in EAs. Conclusions In patients with T2D, adiposity is inversely associated with hippocampal gray and white matter volumes.
KW - Adiposity
KW - African American
KW - Brain
KW - Cognition
KW - Hippocampus
KW - Type 2 diabetes
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U2 - 10.1016/j.jdiacomp.2016.08.012
DO - 10.1016/j.jdiacomp.2016.08.012
M3 - Article
C2 - 27615667
AN - SCOPUS:84994236090
SN - 1056-8727
VL - 30
SP - 1506
EP - 1512
JO - Journal of Diabetes and Its Complications
JF - Journal of Diabetes and Its Complications
IS - 8
ER -