TY - JOUR
T1 - Adiponectin, the past two decades
AU - Wang, Zhao V.
AU - Scherer, Philipp E.
N1 - Funding Information:
This work was supported by a Scientist Development Grant (14SDG18440002) from the American Heart Association (Z.V.W.) and National Institutes of Health grants R01-DK55758, R01-DK099110, and P01-DK088761 (P.E.S.).
Publisher Copyright:
© 2016 The Author (2016). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Adiponectin is an adipocyte-specific factor, first described in 1995. Over the past two decades, numerous studies have elucidated the physiological functions of adiponectin in obesity, diabetes, inflammation, atherosclerosis, and cardiovascular disease. Adiponectin, elicited through cognate receptors, suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle, which together contribute to a beneficial metabolic action in whole body energy homeostasis. Beyond its role in metabolism, adiponectin also protects cells from apoptosis and reduces inflammation in various cell types via receptor-dependent mechanisms. Adiponectin, as a fat-derived hormone, therefore fulfills a critical role as an important messenger to communicate between adipose tissue and other organs. A better understanding of adiponectin actions, including the pros and cons, will advance our insights into basic mechanisms of metabolism and inflammation, and potentially pave the way toward novel means of pharmacological intervention to address pathophysiological changes associated with diabetes, atherosclerosis, and cardiometabolic disease.
AB - Adiponectin is an adipocyte-specific factor, first described in 1995. Over the past two decades, numerous studies have elucidated the physiological functions of adiponectin in obesity, diabetes, inflammation, atherosclerosis, and cardiovascular disease. Adiponectin, elicited through cognate receptors, suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle, which together contribute to a beneficial metabolic action in whole body energy homeostasis. Beyond its role in metabolism, adiponectin also protects cells from apoptosis and reduces inflammation in various cell types via receptor-dependent mechanisms. Adiponectin, as a fat-derived hormone, therefore fulfills a critical role as an important messenger to communicate between adipose tissue and other organs. A better understanding of adiponectin actions, including the pros and cons, will advance our insights into basic mechanisms of metabolism and inflammation, and potentially pave the way toward novel means of pharmacological intervention to address pathophysiological changes associated with diabetes, atherosclerosis, and cardiometabolic disease.
KW - adiponectin
KW - diabetes
KW - metabolic syndrome
KW - obesity
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U2 - 10.1093/jmcb/mjw011
DO - 10.1093/jmcb/mjw011
M3 - Review article
C2 - 26993047
AN - SCOPUS:84965060865
SN - 1674-2788
VL - 8
SP - 93
EP - 100
JO - Journal of molecular cell biology
JF - Journal of molecular cell biology
IS - 2
ER -