Adiponectin, the past two decades

Zhao V. Wang, Philipp E. Scherer

Research output: Contribution to journalReview articlepeer-review

395 Scopus citations


Adiponectin is an adipocyte-specific factor, first described in 1995. Over the past two decades, numerous studies have elucidated the physiological functions of adiponectin in obesity, diabetes, inflammation, atherosclerosis, and cardiovascular disease. Adiponectin, elicited through cognate receptors, suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle, which together contribute to a beneficial metabolic action in whole body energy homeostasis. Beyond its role in metabolism, adiponectin also protects cells from apoptosis and reduces inflammation in various cell types via receptor-dependent mechanisms. Adiponectin, as a fat-derived hormone, therefore fulfills a critical role as an important messenger to communicate between adipose tissue and other organs. A better understanding of adiponectin actions, including the pros and cons, will advance our insights into basic mechanisms of metabolism and inflammation, and potentially pave the way toward novel means of pharmacological intervention to address pathophysiological changes associated with diabetes, atherosclerosis, and cardiometabolic disease.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalJournal of molecular cell biology
Issue number2
StatePublished - Apr 1 2016


  • adiponectin
  • diabetes
  • metabolic syndrome
  • obesity

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology


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