TY - JOUR
T1 - Adiponectin
T2 - Systemic contributor to insulin sensitivity
AU - Pajvani, Utpal B.
AU - Scherer, Philipp E.
N1 - Funding Information:
The authors were supported by a National Institutes of Health Medical Scientist Training Grant T32-GM07288 (UBP) and by an NIH grant R01-DK55758 (to PES).
PY - 2003/6
Y1 - 2003/6
N2 - Adipocyte-specific secreted molecules, termed adipokines, have dispelled the notion of adipose tissue as an inert storage depot for lipids, and highlighted its role as an active endocrine organ that monitors and alters whole-body metabolism and maintains energy homeostasis. One of these adipokines, adiponectin (also known as Acrp30, AdipoQ, and GBP28), has gained significant attention recently as a mediator of insulin sensitivity. Marty clinical reports and genetic studies over the past few years demonstrate decreased circulating levels of this hormone in metabolic dysfunction, such as obesity and insulin resistance, in both humans and animal models. Pharmacologic adiponectin treatments in rodents increase insulin sensitivity, although the primary site and detailed mechanism of action is yet to be determined. The phenotypes of adiponectin-deficient and transgenic adiponectin-overproducing animal models underscore the role of adiponectin in the maintenance of glucose and lipid homeostasis.
AB - Adipocyte-specific secreted molecules, termed adipokines, have dispelled the notion of adipose tissue as an inert storage depot for lipids, and highlighted its role as an active endocrine organ that monitors and alters whole-body metabolism and maintains energy homeostasis. One of these adipokines, adiponectin (also known as Acrp30, AdipoQ, and GBP28), has gained significant attention recently as a mediator of insulin sensitivity. Marty clinical reports and genetic studies over the past few years demonstrate decreased circulating levels of this hormone in metabolic dysfunction, such as obesity and insulin resistance, in both humans and animal models. Pharmacologic adiponectin treatments in rodents increase insulin sensitivity, although the primary site and detailed mechanism of action is yet to be determined. The phenotypes of adiponectin-deficient and transgenic adiponectin-overproducing animal models underscore the role of adiponectin in the maintenance of glucose and lipid homeostasis.
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U2 - 10.1007/s11892-003-0065-2
DO - 10.1007/s11892-003-0065-2
M3 - Review article
C2 - 12762967
AN - SCOPUS:0041519355
SN - 1534-4827
VL - 3
SP - 207
EP - 213
JO - Current diabetes reports
JF - Current diabetes reports
IS - 3
ER -