Adenosine A1 receptors mediate inhibition of cAMP formation in vitro in the pontine, REM sleep induction zone

Gerald A. Marks; Christian G. Birabil; Samuel G. Speciale

doi:10.1016/j.brainres.2005.08.038

Adenosine A1 receptors mediate inhibition of cAMP formation in vitro in the pontine, REM sleep induction zone

Gerald A. Marks, Christian G. Birabil, Samuel G. Speciale

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Microinjection of adenosine A1 receptor agonist or an inhibitor of adenylyl cyclase into the caudal, oral pontine reticular formation (PnOc) of the rat induces a long-lasting increase in REM sleep. Here, we report significant inhibition of forskolin-stimulated cAMP in dissected pontine tissue slices containing the PnOc incubated with the A1 receptor agonist, cyclohexaladenosine (10^-8 M). These data are consistent with adenosine A1 receptor agonist actions on REM sleep mediated through inhibition of cAMP.

Original language	English (US)
Pages (from-to)	124-127
Number of pages	4
Journal	Brain Research
Volume	1061
Issue number	2
DOIs	https://doi.org/10.1016/j.brainres.2005.08.038
State	Published - Nov 9 2005

Keywords

Adenylyl cylase
Cyclohexaladenosine
Forskolin
Pontine reticular formation
Pontine slice

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2005.08.038

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title = "Adenosine A1 receptors mediate inhibition of cAMP formation in vitro in the pontine, REM sleep induction zone",

abstract = "Microinjection of adenosine A1 receptor agonist or an inhibitor of adenylyl cyclase into the caudal, oral pontine reticular formation (PnOc) of the rat induces a long-lasting increase in REM sleep. Here, we report significant inhibition of forskolin-stimulated cAMP in dissected pontine tissue slices containing the PnOc incubated with the A1 receptor agonist, cyclohexaladenosine (10-8 M). These data are consistent with adenosine A1 receptor agonist actions on REM sleep mediated through inhibition of cAMP.",

keywords = "Adenylyl cylase, Cyclohexaladenosine, Forskolin, Pontine reticular formation, Pontine slice",

author = "Marks, {Gerald A.} and Birabil, {Christian G.} and Speciale, {Samuel G.}",

note = "Funding Information: This research was supported by a grant from the National Institute of Mental Health (RO1 MH 57434).",

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T1 - Adenosine A1 receptors mediate inhibition of cAMP formation in vitro in the pontine, REM sleep induction zone

AU - Marks, Gerald A.

AU - Birabil, Christian G.

AU - Speciale, Samuel G.

N1 - Funding Information: This research was supported by a grant from the National Institute of Mental Health (RO1 MH 57434).

PY - 2005/11/9

Y1 - 2005/11/9

N2 - Microinjection of adenosine A1 receptor agonist or an inhibitor of adenylyl cyclase into the caudal, oral pontine reticular formation (PnOc) of the rat induces a long-lasting increase in REM sleep. Here, we report significant inhibition of forskolin-stimulated cAMP in dissected pontine tissue slices containing the PnOc incubated with the A1 receptor agonist, cyclohexaladenosine (10-8 M). These data are consistent with adenosine A1 receptor agonist actions on REM sleep mediated through inhibition of cAMP.

AB - Microinjection of adenosine A1 receptor agonist or an inhibitor of adenylyl cyclase into the caudal, oral pontine reticular formation (PnOc) of the rat induces a long-lasting increase in REM sleep. Here, we report significant inhibition of forskolin-stimulated cAMP in dissected pontine tissue slices containing the PnOc incubated with the A1 receptor agonist, cyclohexaladenosine (10-8 M). These data are consistent with adenosine A1 receptor agonist actions on REM sleep mediated through inhibition of cAMP.

KW - Adenylyl cylase

KW - Cyclohexaladenosine

KW - Forskolin

KW - Pontine reticular formation

KW - Pontine slice

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Adenosine A1 receptors mediate inhibition of cAMP formation in vitro in the pontine, REM sleep induction zone

Abstract

Keywords

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