Adenocarcinoma of the uterine corpus and sarcomas of the uterus

Endometrial cancer remains the only gynecologic malignancy with a rising incidence and mortality. Although diagnostic techniques have evolved modestly, the surgical management of endometrial cancer was transformed with incorporation of sentinel lymph node dissection paradigms. Furthermore, significant gains have been achieved in molecular characterization of endometrial cancer, with publication of The Cancer Genome Atlas (TCGA) endometrial and subsequent studies. Incorporation of molecular diagnostics has ushered in immunotherapy as an effective treatment strategy in select patients, with alternate targeted therapies emerging as promising options.