Acute-On-Chronic Liver Failure

Sumeet K. Asrani, Jacqueline G. O'Leary

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


The Model for End-Stage Liver Disease (MELD) has been the single best predictor of outcome of the progression of cirrhosis. Acute-on-chronic liver failure (ACLF) has been proposed as an alternative path in the natural history of cirrhosis. ACLF occurs in patients with chronic liver disease and is characterized by a precipitating event, resulting in acute deterioration in liver function, multiorgan system failure, and high short-term mortality. In this review, the natural course of patients with ACLF, especially as it relates to management of cirrhotic patients on the transplant waiting list, and its impact on liver transplantation outcomes are defined.

Original languageEnglish (US)
Pages (from-to)561-574
Number of pages14
JournalClinics in Liver Disease
Issue number3
StatePublished - Aug 2014


  • Acute liver failure
  • Acute-on-chronic liver failure
  • Cirrhosis
  • Liver transplantation
  • Organ failure

ASJC Scopus subject areas

  • Hepatology


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