TY - JOUR
T1 - Acute Liver Failure Guidelines
AU - Shingina, Alexandra
AU - Mukhtar, Nizar
AU - Wakim-Fleming, Jamilé
AU - Alqahtani, Saleh
AU - Wong, Robert J.
AU - Limketkai, Berkeley N.
AU - Larson, Anne M.
AU - Grant, Lafaine
N1 - Publisher Copyright:
© 2023 Wolters Kluwer Health. All rights reserved.
PY - 2023/7/1
Y1 - 2023/7/1
N2 - Acute liver failure (ALF) is a rare, acute, potentially reversible condition resulting in severe liver impairment and rapid clinical deterioration in patients without preexisting liver disease. Due to the rarity of this condition, published studies are limited by the use of retrospective or prospective cohorts and lack of randomized controlled trials. Current guidelines represent the suggested approach to the identification, treatment, and management of ALF and represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence was reviewed using the Grading of Recommendations, Assessment, Development and Evaluation process to develop recommendations. When no robust evidence was available, expert opinions were summarized using Key Concepts. Considering the variety of clinical presentations of ALF, individualization of care should be applied in specific clinical scenarios.
AB - Acute liver failure (ALF) is a rare, acute, potentially reversible condition resulting in severe liver impairment and rapid clinical deterioration in patients without preexisting liver disease. Due to the rarity of this condition, published studies are limited by the use of retrospective or prospective cohorts and lack of randomized controlled trials. Current guidelines represent the suggested approach to the identification, treatment, and management of ALF and represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence was reviewed using the Grading of Recommendations, Assessment, Development and Evaluation process to develop recommendations. When no robust evidence was available, expert opinions were summarized using Key Concepts. Considering the variety of clinical presentations of ALF, individualization of care should be applied in specific clinical scenarios.
KW - Acute liver failure
KW - acute liver injury
KW - coagulopathy
KW - fulminant liver failure
KW - hepatic encephalopathy
KW - hepatotoxicity
KW - jaundice
KW - liver transplantation
KW - multi-organ failure
UR - http://www.scopus.com/inward/record.url?scp=85164210704&partnerID=8YFLogxK
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U2 - 10.14309/ajg.0000000000002340
DO - 10.14309/ajg.0000000000002340
M3 - Article
C2 - 37377263
AN - SCOPUS:85164210704
SN - 0002-9270
VL - 118
SP - 1128
EP - 1153
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 7
ER -