Abstract
Induction of acute hypervitaminosis A in the guinea pig can substantially suppress delayed-type hypersensitivity and Arthus reactivity of moderate intensity and the inflammatory response to intradermal injection of diphtheria toxin. No effect of Vit. A was demonstrated on the clearance of bacteriophage φX 174 from the circulation or on antibody formation to the phage. The results suggest that acute hypervitaminosis A can suppress inflammatory responses of moderate intensity in the skin of guinea pigs, possibly as a consequence of an action on lysosomes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 287-291 |
| Number of pages | 5 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 112 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1963 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology