TY - JOUR
T1 - Acute hemodynamic responses to electroconvulsive therapy are not related to the duration of seizure activity
AU - Fu, Wen
AU - Stool, Louis A.
AU - White, Paul F.
AU - Husain, Mustafa M.
PY - 1997/12
Y1 - 1997/12
N2 - Study Objective: To test the hypothesis that the magnitude of the acute hemodynamic response to electroconvulsive therapy (ECT) is related to the duration of the seizure activity in patients receiving different dosages of intravenous (IV) lidocaine. Design: Randomized, double-blind, placebo- controlled, cross-over study. Setting: University-affiliated hospital. Patients: 21 ASA physical statues I, II, and III patients undergoing four consecutive maintenance ECT treatments for chronic depression. Interventions: Patients received lidocaine 50 mg, 100 mg, 200 mg IV, or saline prior to induction of anesthesia via a standardized anesthetic technique. Measurements and Main Results: Noninvasive blood pressure (BP) and heart, rate (HR), as well as the duration of motor and electroencephalographic (EEG) seizure, were measured. The duration of motor and EEG seizures (means ± SD) were 37 ± 13 sec and 64 ± 21 sec, 25 ± 11 sec and 52 ± 43 sec, 17 ± 12 sec and 32 ± 17 sec, 1 ± 3 sec and 18 ± 10 sec in the saline, lidocaine 50 mg, 100 mg, 200 mg groups, respectively. Although the duration of seizure activity was decreased in a dose-related fashion after lidocaine pretreatment, the peak increases in BP and HR were similar in the lidocaine and saline treatment groups. Conclusions: Despite producing dose-related decreases in the duration of both motor and EEG seizure activity, lidocaine failed to attenuate the acute hemodynamic response to ECT. Thus, the acute hemodynamic response to ECT is not related to the duration of seizure activity.
AB - Study Objective: To test the hypothesis that the magnitude of the acute hemodynamic response to electroconvulsive therapy (ECT) is related to the duration of the seizure activity in patients receiving different dosages of intravenous (IV) lidocaine. Design: Randomized, double-blind, placebo- controlled, cross-over study. Setting: University-affiliated hospital. Patients: 21 ASA physical statues I, II, and III patients undergoing four consecutive maintenance ECT treatments for chronic depression. Interventions: Patients received lidocaine 50 mg, 100 mg, 200 mg IV, or saline prior to induction of anesthesia via a standardized anesthetic technique. Measurements and Main Results: Noninvasive blood pressure (BP) and heart, rate (HR), as well as the duration of motor and electroencephalographic (EEG) seizure, were measured. The duration of motor and EEG seizures (means ± SD) were 37 ± 13 sec and 64 ± 21 sec, 25 ± 11 sec and 52 ± 43 sec, 17 ± 12 sec and 32 ± 17 sec, 1 ± 3 sec and 18 ± 10 sec in the saline, lidocaine 50 mg, 100 mg, 200 mg groups, respectively. Although the duration of seizure activity was decreased in a dose-related fashion after lidocaine pretreatment, the peak increases in BP and HR were similar in the lidocaine and saline treatment groups. Conclusions: Despite producing dose-related decreases in the duration of both motor and EEG seizure activity, lidocaine failed to attenuate the acute hemodynamic response to ECT. Thus, the acute hemodynamic response to ECT is not related to the duration of seizure activity.
KW - Anesthetics, local: lidocaine
KW - Electroconvulsive therapy
KW - Electroencephalography: seizure activity
KW - Hypertension
UR - http://www.scopus.com/inward/record.url?scp=0031451735&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031451735&partnerID=8YFLogxK
U2 - 10.1016/S0952-8180(97)00191-8
DO - 10.1016/S0952-8180(97)00191-8
M3 - Article
C2 - 9438894
AN - SCOPUS:0031451735
SN - 0952-8180
VL - 9
SP - 653
EP - 657
JO - Journal of Clinical Anesthesia
JF - Journal of Clinical Anesthesia
IS - 8
ER -