TY - JOUR
T1 - Active MHC class Ib genes in rat are pseudogenes in the mouse
AU - Lambracht-Washington, Doris
AU - Lindahl, Kirsten Fischer
N1 - Funding Information:
Acknowledgement This work was supported in part by NIH grant AI 37818.
PY - 2004/5
Y1 - 2004/5
N2 - The most telomeric class I region of the MHC in rat and mouse is the M region, which contains about 20 class I genes or gene fragments. The central part carries three class I genes - M4, M5, and M6 - which are orthologous between the two species. M4 and M6 are pseudogenes in the mouse but transcribed, intact genes in the rat. To analyze the pseudogene status for the mouse genes in more detail, we have sequenced the respective exons in multiple representative haplotypes. The stop codons are conserved in all mouse strains analyzed, and, consistent with the pseudogene status, all strains show additional insertions and deletions, taking the genes further away from functionality. Thus, M4 and M6 indeed have a split status. They are silent in the mouse but intact in the closely related rodent, the rat.
AB - The most telomeric class I region of the MHC in rat and mouse is the M region, which contains about 20 class I genes or gene fragments. The central part carries three class I genes - M4, M5, and M6 - which are orthologous between the two species. M4 and M6 are pseudogenes in the mouse but transcribed, intact genes in the rat. To analyze the pseudogene status for the mouse genes in more detail, we have sequenced the respective exons in multiple representative haplotypes. The stop codons are conserved in all mouse strains analyzed, and, consistent with the pseudogene status, all strains show additional insertions and deletions, taking the genes further away from functionality. Thus, M4 and M6 indeed have a split status. They are silent in the mouse but intact in the closely related rodent, the rat.
KW - H2-M region
KW - Interspecies comparison
KW - Orthologous genes
KW - Pseudogenes
KW - RT1.M region
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U2 - 10.1007/s00251-004-0671-4
DO - 10.1007/s00251-004-0671-4
M3 - Article
C2 - 15069589
AN - SCOPUS:2942615487
SN - 0093-7711
VL - 56
SP - 118
EP - 121
JO - Immunogenetics
JF - Immunogenetics
IS - 2
ER -