TY - JOUR
T1 - Activation of telomerase in human lymphocytes and hematopoietic progenitor cells
AU - Hiyama, K.
AU - Hirai, Y.
AU - Kyoizumi, S.
AU - Akiyama, M.
AU - Hiyama, E.
AU - Piatyszek, M. A.
AU - Shay, J. W.
AU - Ishioka, S.
AU - Yamakido, M.
PY - 1995
Y1 - 1995
N2 - This is the first report describing up-regulation of telomerase activity in human normal cells. Telomerase, a ribonucleoprotein enzyme, has been thought to be involved in maintaining telomere length stability in germline and most cancer cells, but not in normal cells. However, in the present study, we demonstrate that telomerase activity is detectable at low levels in normal human T and B cells, increases by in vitro mitogenic stimulation, increases in hematopoietic progenitor cells upon their proliferation and differentiation, and decreases with aging. Understanding the regulation of telomerase activity in normal cells may provide important insights not only into the mechanisms of normal cellular senescence but also into the mechanisms of telomerase activity deregulation as part of cancer development.
AB - This is the first report describing up-regulation of telomerase activity in human normal cells. Telomerase, a ribonucleoprotein enzyme, has been thought to be involved in maintaining telomere length stability in germline and most cancer cells, but not in normal cells. However, in the present study, we demonstrate that telomerase activity is detectable at low levels in normal human T and B cells, increases by in vitro mitogenic stimulation, increases in hematopoietic progenitor cells upon their proliferation and differentiation, and decreases with aging. Understanding the regulation of telomerase activity in normal cells may provide important insights not only into the mechanisms of normal cellular senescence but also into the mechanisms of telomerase activity deregulation as part of cancer development.
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M3 - Article
C2 - 7561072
AN - SCOPUS:0029091386
SN - 0022-1767
VL - 155
SP - 3711
EP - 3715
JO - Journal of Immunology
JF - Journal of Immunology
IS - 8
ER -