Activated Acinus boosts basal autophagy

Nilay Nandi; Lauren K. Tyra; Helmut Krämer

doi:10.4161/23723556.2014.995043

Activated Acinus boosts basal autophagy

Nilay Nandi, Lauren K. Tyra, Helmut Krämer

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Acinus (Acn) is a nuclear protein that participates in the regulation of autophagy. Loss of Acn function prevents autophagy in starving cells. Conversely, Acn activation induces basal autophagy. This enhances the quality control functions of autophagy such as the removal of misfolded proteins, thereby reducing neurodegeneration and prolonging lifespan. Acn activity is enhanced by Akt1-mediated phosphorylation, which counteracts the cleavage of Acn by a caspase-3 homolog.

Original language	English (US)
Article number	e995043
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/23723556.2014.995043
State	Published - Jul 3 2015

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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title = "Activated Acinus boosts basal autophagy",

abstract = "Acinus (Acn) is a nuclear protein that participates in the regulation of autophagy. Loss of Acn function prevents autophagy in starving cells. Conversely, Acn activation induces basal autophagy. This enhances the quality control functions of autophagy such as the removal of misfolded proteins, thereby reducing neurodegeneration and prolonging lifespan. Acn activity is enhanced by Akt1-mediated phosphorylation, which counteracts the cleavage of Acn by a caspase-3 homolog.",

author = "Nilay Nandi and Tyra, {Lauren K.} and Helmut Kr{\"a}mer",

note = "Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2015, {\textcopyright} Nilay Nandi, Lauren K Tyra, and Helmut Kr{\"a}mer.",

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AU - Tyra, Lauren K.

AU - Krämer, Helmut

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N2 - Acinus (Acn) is a nuclear protein that participates in the regulation of autophagy. Loss of Acn function prevents autophagy in starving cells. Conversely, Acn activation induces basal autophagy. This enhances the quality control functions of autophagy such as the removal of misfolded proteins, thereby reducing neurodegeneration and prolonging lifespan. Acn activity is enhanced by Akt1-mediated phosphorylation, which counteracts the cleavage of Acn by a caspase-3 homolog.

AB - Acinus (Acn) is a nuclear protein that participates in the regulation of autophagy. Loss of Acn function prevents autophagy in starving cells. Conversely, Acn activation induces basal autophagy. This enhances the quality control functions of autophagy such as the removal of misfolded proteins, thereby reducing neurodegeneration and prolonging lifespan. Acn activity is enhanced by Akt1-mediated phosphorylation, which counteracts the cleavage of Acn by a caspase-3 homolog.

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Activated Acinus boosts basal autophagy

Abstract

ASJC Scopus subject areas

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