Actin-Membrane Release Initiates Cell Protrusions

Erik S. Welf; Christopher E. Miles; Jaewon Huh; Etai Sapoznik; Joseph Chi; Meghan K. Driscoll; Tadamoto Isogai; Jungsik Noh; Andrew D. Weems; Theresa Pohlkamp; Kevin Dean; Reto Fiolka; Alex Mogilner; Gaudenz Danuser

doi:10.1016/j.devcel.2020.11.024

Actin-Membrane Release Initiates Cell Protrusions

Erik S. Welf, Christopher E. Miles, Jaewon Huh, Etai Sapoznik, Joseph Chi, Meghan K. Driscoll, Tadamoto Isogai, Jungsik Noh, Andrew D. Weems, Theresa Pohlkamp, Kevin Dean, Reto Fiolka, Alex Mogilner, Gaudenz Danuser

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Using experiments and mathematical modeling, Welf et al. identify that plasma membrane detachment from actin is needed to initiate cell protrusion, regardless of whether actin polymerization or intracellular pressure create pushing forces. Their actin release model augments the tethered Brownian ratchet model, explaining why actin polymerization alone cannot initiate protrusion.

Original language	English (US)
Pages (from-to)	723-736.e8
Journal	Developmental cell
Volume	55
Issue number	6
DOIs	https://doi.org/10.1016/j.devcel.2020.11.024
State	Published - Dec 21 2020

Keywords

Brownian ratchet model
actin dynamics
cytoskeleton
intracellular force
lamellipodium
morphology
polymerization
protrusion
shape change

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2020.11.024

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title = "Actin-Membrane Release Initiates Cell Protrusions",

abstract = "Using experiments and mathematical modeling, Welf et al. identify that plasma membrane detachment from actin is needed to initiate cell protrusion, regardless of whether actin polymerization or intracellular pressure create pushing forces. Their actin release model augments the tethered Brownian ratchet model, explaining why actin polymerization alone cannot initiate protrusion.",

keywords = "Brownian ratchet model, actin dynamics, cytoskeleton, intracellular force, lamellipodium, morphology, polymerization, protrusion, shape change",

author = "Welf, {Erik S.} and Miles, {Christopher E.} and Jaewon Huh and Etai Sapoznik and Joseph Chi and Driscoll, {Meghan K.} and Tadamoto Isogai and Jungsik Noh and Weems, {Andrew D.} and Theresa Pohlkamp and Kevin Dean and Reto Fiolka and Alex Mogilner and Gaudenz Danuser",

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year = "2020",

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doi = "10.1016/j.devcel.2020.11.024",

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TY - JOUR

T1 - Actin-Membrane Release Initiates Cell Protrusions

AU - Welf, Erik S.

AU - Miles, Christopher E.

AU - Huh, Jaewon

AU - Sapoznik, Etai

AU - Chi, Joseph

AU - Driscoll, Meghan K.

AU - Isogai, Tadamoto

AU - Noh, Jungsik

AU - Weems, Andrew D.

AU - Pohlkamp, Theresa

AU - Dean, Kevin

AU - Fiolka, Reto

AU - Mogilner, Alex

AU - Danuser, Gaudenz

PY - 2020/12/21

Y1 - 2020/12/21

N2 - Using experiments and mathematical modeling, Welf et al. identify that plasma membrane detachment from actin is needed to initiate cell protrusion, regardless of whether actin polymerization or intracellular pressure create pushing forces. Their actin release model augments the tethered Brownian ratchet model, explaining why actin polymerization alone cannot initiate protrusion.

AB - Using experiments and mathematical modeling, Welf et al. identify that plasma membrane detachment from actin is needed to initiate cell protrusion, regardless of whether actin polymerization or intracellular pressure create pushing forces. Their actin release model augments the tethered Brownian ratchet model, explaining why actin polymerization alone cannot initiate protrusion.

KW - Brownian ratchet model

KW - actin dynamics

KW - cytoskeleton

KW - intracellular force

KW - lamellipodium

KW - morphology

KW - polymerization

KW - protrusion

KW - shape change

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U2 - 10.1016/j.devcel.2020.11.024

DO - 10.1016/j.devcel.2020.11.024

M3 - Article

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AN - SCOPUS:85098470112

SN - 1534-5807

VL - 55

SP - 723-736.e8

JO - Developmental cell

JF - Developmental cell

IS - 6

ER -

Actin-Membrane Release Initiates Cell Protrusions

Abstract

Keywords

ASJC Scopus subject areas

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