Acquired von Willebrand syndrome secondary to mitral and aortic regurgitation

Siu Hin Wan; Jackson J. Liang; Rakhee Vaidya; Joseph L. Blackshear; Dong Chen

doi:10.1016/j.cjca.2014.02.010

Acquired von Willebrand syndrome secondary to mitral and aortic regurgitation

Siu Hin Wan, Jackson J. Liang, Rakhee Vaidya, Joseph L. Blackshear, Dong Chen

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The association between aortic stenosis and gastrointenstinal bleeding due to acquired von Willebrand syndrome (AVWS) has been well established. We report a patient with AVWS from underlying severe endocarditis-associated aortic regurgitation and pre-existing mitral regurgitation. Cardiovascular disease-related AVWS occurs from a selective loss of the largest multimers of von Willebrand factor from highshear forces, and desmopressin leads to transient clinical improvement.

Original language	English (US)
Pages (from-to)	1108.e9-1108.e10
Journal	Canadian Journal of Cardiology
Volume	30
Issue number	9
DOIs	https://doi.org/10.1016/j.cjca.2014.02.010
State	Published - Sep 2014
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.cjca.2014.02.010

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abstract = "The association between aortic stenosis and gastrointenstinal bleeding due to acquired von Willebrand syndrome (AVWS) has been well established. We report a patient with AVWS from underlying severe endocarditis-associated aortic regurgitation and pre-existing mitral regurgitation. Cardiovascular disease-related AVWS occurs from a selective loss of the largest multimers of von Willebrand factor from highshear forces, and desmopressin leads to transient clinical improvement.",

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AU - Liang, Jackson J.

AU - Vaidya, Rakhee

AU - Blackshear, Joseph L.

AU - Chen, Dong

PY - 2014/9

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AB - The association between aortic stenosis and gastrointenstinal bleeding due to acquired von Willebrand syndrome (AVWS) has been well established. We report a patient with AVWS from underlying severe endocarditis-associated aortic regurgitation and pre-existing mitral regurgitation. Cardiovascular disease-related AVWS occurs from a selective loss of the largest multimers of von Willebrand factor from highshear forces, and desmopressin leads to transient clinical improvement.

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Acquired von Willebrand syndrome secondary to mitral and aortic regurgitation

Abstract

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