Acquired von Willebrand syndrome secondary to mitral and aortic regurgitation

Siu Hin Wan, Jackson J. Liang, Rakhee Vaidya, Joseph L. Blackshear, Dong Chen

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The association between aortic stenosis and gastrointenstinal bleeding due to acquired von Willebrand syndrome (AVWS) has been well established. We report a patient with AVWS from underlying severe endocarditis-associated aortic regurgitation and pre-existing mitral regurgitation. Cardiovascular disease-related AVWS occurs from a selective loss of the largest multimers of von Willebrand factor from highshear forces, and desmopressin leads to transient clinical improvement.

Original languageEnglish (US)
Pages (from-to)1108.e9-1108.e10
JournalCanadian Journal of Cardiology
Issue number9
StatePublished - Sep 2014
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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