TY - JOUR
T1 - Aberrant somatosensory phase synchronization in children with hemiplegic cerebral palsy
AU - Song, Yanlong
AU - Renoul, Emmanuelle
AU - Acord, Stephanie
AU - Johnson, Yvette R.
AU - Marks, Warren
AU - Alexandrakis, George
AU - Papadelis, Christos
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/9/25
Y1 - 2021/9/25
N2 - Children with hemiplegic cerebral palsy (HCP) often show disturbances of somatosensation. Despite extensive evidence of somatosensory deficits, neurophysiological alterations associated with somatosensory deficits in children with HCP have not been elucidated. Here, we aim to assess phase synchrony within and between contralateral primary (S1) and secondary (S2) somatosensory areas in children with HCP. Intra-regional and inter-regional phase synchronizations within and between S1 and S2 were estimated from somatosensory evoked fields (SEFs) in response to passive pneumatic stimulation of contralateral upper extremities and recorded with pediatric magnetoencephalography (MEG) in children with HCP and typically developing (TD) children. We found aberrant phase synchronizations within S1 and between S1 and S2 in both hemispheres in children with HCP. Specifically, the less-affected (LA) hemisphere demonstrated diminished phase synchronizations after the stimulus onset up to ~120 ms compared to the more-affected (MA) hemisphere and the dominant hemisphere of TD children, while the MA hemisphere showed enhanced phase synchronizations after ~100 ms compared to the LA hemisphere and the TD dominant hemisphere. Our findings indicate abnormal somatosensory functional connectivity in both hemispheres of children with HCP.
AB - Children with hemiplegic cerebral palsy (HCP) often show disturbances of somatosensation. Despite extensive evidence of somatosensory deficits, neurophysiological alterations associated with somatosensory deficits in children with HCP have not been elucidated. Here, we aim to assess phase synchrony within and between contralateral primary (S1) and secondary (S2) somatosensory areas in children with HCP. Intra-regional and inter-regional phase synchronizations within and between S1 and S2 were estimated from somatosensory evoked fields (SEFs) in response to passive pneumatic stimulation of contralateral upper extremities and recorded with pediatric magnetoencephalography (MEG) in children with HCP and typically developing (TD) children. We found aberrant phase synchronizations within S1 and between S1 and S2 in both hemispheres in children with HCP. Specifically, the less-affected (LA) hemisphere demonstrated diminished phase synchronizations after the stimulus onset up to ~120 ms compared to the more-affected (MA) hemisphere and the dominant hemisphere of TD children, while the MA hemisphere showed enhanced phase synchronizations after ~100 ms compared to the LA hemisphere and the TD dominant hemisphere. Our findings indicate abnormal somatosensory functional connectivity in both hemispheres of children with HCP.
KW - Cerebral palsy
KW - Functional connectivity
KW - Magnetoencephalography
KW - Phase synchronization
KW - Primary somatosensory cortex
KW - Secondary somatosensory cortex
UR - http://www.scopus.com/inward/record.url?scp=85113242684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85113242684&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2021.136169
DO - 10.1016/j.neulet.2021.136169
M3 - Article
C2 - 34390772
AN - SCOPUS:85113242684
SN - 0304-3940
VL - 762
JO - Neuroscience letters
JF - Neuroscience letters
M1 - 136169
ER -