Abdominal wall reconstruction using biological tissue grafts: Present status and future opportunities

Charles F. Bellows, Adam Alder, W. Scott Helton

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations


Surgeons often encounter the challenge of treating acquired abdominal wall defects following abdominal surgery. The current standard of practice is to repair most defects using permanent synthetic mesh material. Mesh augments the strength of the weakened abdominal wall fascia and enables the hernia repair to be performed in a tension-free manner. However, there is a risk of acute and/or chronic infection, fistula formation and chronic abdominal wall pain with the use of permanent mesh materials, which can lead to more complex operations. As a means to avoid such problems, surgeons are turning increasingly to the use of xenogenic and allogenic materials for the repair of abdominal wall defects. Their rapid evolution and introduction into the clinical operating room is leading to a now era in abdominal wall reconstruction. There are promising, albeit limited, clinical data with short-term follow-up for only a few of the many biological tissue grafts that are being promoted currently for the repair of abdominal hernias. Additional clinical, studies are required to better understand the long-term efficacy and limitations of these materials.

Original languageEnglish (US)
Pages (from-to)657-675
Number of pages19
JournalExpert review of medical devices
Issue number5
StatePublished - Sep 1 2006


  • Abdominal wall reconstruction
  • Biological tissue grafts
  • Mesh

ASJC Scopus subject areas

  • Surgery
  • Biomedical Engineering


Dive into the research topics of 'Abdominal wall reconstruction using biological tissue grafts: Present status and future opportunities'. Together they form a unique fingerprint.

Cite this