A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers

Avner Thaler; Moran Artzi; Anat Mirelman; Yael Jacob; Rick C. Helmich; Bart F.L. van Nuenen; Tanya Gurevich; Avi Orr-Urtreger; Karen Marder; Susan Bressman; Bastiaan R. Bloem; Talma Hendler; Nir Giladi; Dafna Ben Bashat; Rachel Saunders-Pullman; Vicki Lynn Shanker; Mark Groves; Christine Palmese; Kaili Maloy Stanley; Akhila Iyer; Jeannie Soto-Valencia; Deborah Raymond; Marta San Luciano; Andres Deik; Matthew James Barrette; Jose Cabbasa; Lawrence Severt; Ann Hunt; Naomi Lubarr; Rivka Sachdev; Sara Lewis; Laurie Ozelius; Roy Alcalay; Stanley Fahn; Lucien Cote; Paul Greene; Cheryl Waters; Pietro Mazzoni; Blair Ford; Elan Louis; Oren Levy; Ming Xin Tang; Brian Rakitin; Helen Mejia; Ernest Roos; Martha Orbe Riley; Llency Rosado; Carol Moskowitz; Tsvyatko Dorovski; Lorraine Clark; Xinmin Liu; Sergey Kisselev; Itsik Peer; Vladimir Vacic; Yaacov Balash; Shabtai Hertzel; Ziv Gan Or; Anat Bar Shira; Mali Gana Weiss; Hila Kobo; Noa Bregman; Meir Kestenbaum; Hedva Lehrman; Einat Even Sapir; Shiran Levy; Kira Yasinovsky; Anat Shkedy; Maayan Zelis

doi:10.1002/mds.25827

A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers

Avner Thaler, Moran Artzi, Anat Mirelman, Yael Jacob, Rick C. Helmich, Bart F.L. van Nuenen, Tanya Gurevich, Avi Orr-Urtreger, Karen Marder, Susan Bressman, Bastiaan R. Bloem, Talma Hendler, Nir Giladi, Dafna Ben Bashat, Rachel Saunders-Pullman, Vicki Lynn Shanker, Mark Groves, Christine Palmese, Kaili Maloy Stanley, Akhila IyerJeannie Soto-Valencia, Deborah Raymond, Marta San Luciano, Andres Deik, Matthew James Barrette, Jose Cabbasa, Lawrence Severt, Ann Hunt, Naomi Lubarr, Rivka Sachdev, Sara Lewis, Laurie Ozelius, Roy Alcalay, Stanley Fahn, Lucien Cote, Paul Greene, Cheryl Waters, Pietro Mazzoni, Blair Ford, Elan Louis, Oren Levy, Ming Xin Tang, Brian Rakitin, Helen Mejia, Ernest Roos, Martha Orbe Riley, Llency Rosado, Carol Moskowitz, Tsvyatko Dorovski, Lorraine Clark, Xinmin Liu, Sergey Kisselev, Itsik Peer, Vladimir Vacic, Yaacov Balash, Shabtai Hertzel, Ziv Gan Or, Anat Bar Shira, Mali Gana Weiss, Hila Kobo, Noa Bregman, Meir Kestenbaum, Hedva Lehrman, Einat Even Sapir, Shiran Levy, Kira Yasinovsky, Anat Shkedy, Maayan Zelis

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Background: Patients with Parkinson's disease have reduced gray matter volume and fractional anisotropy in both cortical and sub-cortical structures, yet changes in the pre-motor phase of the disease are unknown. Methods: A comprehensive imaging study using voxel-based morphometry and diffusion tensor imaging tract-based spatial statistics analysis was performed on 64 Ashkenazi Jewish asymptomatic first degree relatives of patients with Parkinson's disease (30 mutation carriers), who carry the G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene. Results: No between-group differences in gray matter volume could be noted in either whole-brain or volume-of-interest analysis. Diffusion tensor imaging analysis did not identify group differences in white matter areas, and volume-of-interest analysis identified no differences in diffusivity parameters in Parkinson's disease-related structures. Conclusions: G2019S carriers do not manifest changes in gray matter volume or diffusivity parameters in Parkinson's disease-related structures prior to the appearance of motor symptoms.

Original language	English (US)
Pages (from-to)	823-827
Number of pages	5
Journal	Movement Disorders
Volume	29
Issue number	6
DOIs	https://doi.org/10.1002/mds.25827
State	Published - May 2014
Externally published	Yes

Keywords

Diffusion tensor imaging
G2019S
LRRK2
Magnetic resonance imaging
Parkinson's disease
Voxel-based morphometry

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.25827

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Thaler, A., Artzi, M., Mirelman, A., Jacob, Y., Helmich, R. C., van Nuenen, B. F. L., Gurevich, T., Orr-Urtreger, A., Marder, K., Bressman, S., Bloem, B. R., Hendler, T., Giladi, N., Ben Bashat, D., Saunders-Pullman, R., Shanker, V. L., Groves, M., Palmese, C., Stanley, K. M., ... Zelis, M. (2014). A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers. Movement Disorders, 29(6), 823-827. https://doi.org/10.1002/mds.25827

Thaler, A, Artzi, M, Mirelman, A, Jacob, Y, Helmich, RC, van Nuenen, BFL, Gurevich, T, Orr-Urtreger, A, Marder, K, Bressman, S, Bloem, BR, Hendler, T, Giladi, N, Ben Bashat, D, Saunders-Pullman, R, Shanker, VL, Groves, M, Palmese, C, Stanley, KM, Iyer, A, Soto-Valencia, J, Raymond, D, San Luciano, M, Deik, A, Barrette, MJ, Cabbasa, J, Severt, L, Hunt, A, Lubarr, N, Sachdev, R, Lewis, S, Ozelius, L, Alcalay, R, Fahn, S, Cote, L, Greene, P, Waters, C, Mazzoni, P, Ford, B, Louis, E, Levy, O, Tang, MX, Rakitin, B, Mejia, H, Roos, E, Riley, MO, Rosado, L, Moskowitz, C, Dorovski, T, Clark, L, Liu, X, Kisselev, S, Peer, I, Vacic, V, Balash, Y, Hertzel, S, Or, ZG, Shira, AB, Weiss, MG, Kobo, H, Bregman, N, Kestenbaum, M, Lehrman, H, Sapir, EE, Levy, S, Yasinovsky, K, Shkedy, A & Zelis, M 2014, 'A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers', Movement Disorders, vol. 29, no. 6, pp. 823-827. https://doi.org/10.1002/mds.25827

@article{8863bf831b17459a99e41b6b7bfff238,

title = "A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers",

abstract = "Background: Patients with Parkinson's disease have reduced gray matter volume and fractional anisotropy in both cortical and sub-cortical structures, yet changes in the pre-motor phase of the disease are unknown. Methods: A comprehensive imaging study using voxel-based morphometry and diffusion tensor imaging tract-based spatial statistics analysis was performed on 64 Ashkenazi Jewish asymptomatic first degree relatives of patients with Parkinson's disease (30 mutation carriers), who carry the G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene. Results: No between-group differences in gray matter volume could be noted in either whole-brain or volume-of-interest analysis. Diffusion tensor imaging analysis did not identify group differences in white matter areas, and volume-of-interest analysis identified no differences in diffusivity parameters in Parkinson's disease-related structures. Conclusions: G2019S carriers do not manifest changes in gray matter volume or diffusivity parameters in Parkinson's disease-related structures prior to the appearance of motor symptoms.",

keywords = "Diffusion tensor imaging, G2019S, LRRK2, Magnetic resonance imaging, Parkinson's disease, Voxel-based morphometry",

author = "Avner Thaler and Moran Artzi and Anat Mirelman and Yael Jacob and Helmich, {Rick C.} and {van Nuenen}, {Bart F.L.} and Tanya Gurevich and Avi Orr-Urtreger and Karen Marder and Susan Bressman and Bloem, {Bastiaan R.} and Talma Hendler and Nir Giladi and {Ben Bashat}, Dafna and Rachel Saunders-Pullman and Shanker, {Vicki Lynn} and Mark Groves and Christine Palmese and Stanley, {Kaili Maloy} and Akhila Iyer and Jeannie Soto-Valencia and Deborah Raymond and {San Luciano}, Marta and Andres Deik and Barrette, {Matthew James} and Jose Cabbasa and Lawrence Severt and Ann Hunt and Naomi Lubarr and Rivka Sachdev and Sara Lewis and Laurie Ozelius and Roy Alcalay and Stanley Fahn and Lucien Cote and Paul Greene and Cheryl Waters and Pietro Mazzoni and Blair Ford and Elan Louis and Oren Levy and Tang, {Ming Xin} and Brian Rakitin and Helen Mejia and Ernest Roos and Riley, {Martha Orbe} and Llency Rosado and Carol Moskowitz and Tsvyatko Dorovski and Lorraine Clark and Xinmin Liu and Sergey Kisselev and Itsik Peer and Vladimir Vacic and Yaacov Balash and Shabtai Hertzel and Or, {Ziv Gan} and Shira, {Anat Bar} and Weiss, {Mali Gana} and Hila Kobo and Noa Bregman and Meir Kestenbaum and Hedva Lehrman and Sapir, {Einat Even} and Shiran Levy and Kira Yasinovsky and Anat Shkedy and Maayan Zelis",

year = "2014",

month = may,

doi = "10.1002/mds.25827",

language = "English (US)",

volume = "29",

pages = "823--827",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley and Sons Inc.",

number = "6",

}

TY - JOUR

T1 - A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers

AU - Thaler, Avner

AU - Artzi, Moran

AU - Mirelman, Anat

AU - Jacob, Yael

AU - Helmich, Rick C.

AU - van Nuenen, Bart F.L.

AU - Gurevich, Tanya

AU - Orr-Urtreger, Avi

AU - Marder, Karen

AU - Bressman, Susan

AU - Bloem, Bastiaan R.

AU - Hendler, Talma

AU - Giladi, Nir

AU - Ben Bashat, Dafna

AU - Saunders-Pullman, Rachel

AU - Shanker, Vicki Lynn

AU - Groves, Mark

AU - Palmese, Christine

AU - Stanley, Kaili Maloy

AU - Iyer, Akhila

AU - Soto-Valencia, Jeannie

AU - Raymond, Deborah

AU - San Luciano, Marta

AU - Deik, Andres

AU - Barrette, Matthew James

AU - Cabbasa, Jose

AU - Severt, Lawrence

AU - Hunt, Ann

AU - Lubarr, Naomi

AU - Sachdev, Rivka

AU - Lewis, Sara

AU - Ozelius, Laurie

AU - Alcalay, Roy

AU - Fahn, Stanley

AU - Cote, Lucien

AU - Greene, Paul

AU - Waters, Cheryl

AU - Mazzoni, Pietro

AU - Ford, Blair

AU - Louis, Elan

AU - Levy, Oren

AU - Tang, Ming Xin

AU - Rakitin, Brian

AU - Mejia, Helen

AU - Roos, Ernest

AU - Riley, Martha Orbe

AU - Rosado, Llency

AU - Moskowitz, Carol

AU - Dorovski, Tsvyatko

AU - Clark, Lorraine

AU - Liu, Xinmin

AU - Kisselev, Sergey

AU - Peer, Itsik

AU - Vacic, Vladimir

AU - Balash, Yaacov

AU - Hertzel, Shabtai

AU - Or, Ziv Gan

AU - Shira, Anat Bar

AU - Weiss, Mali Gana

AU - Kobo, Hila

AU - Bregman, Noa

AU - Kestenbaum, Meir

AU - Lehrman, Hedva

AU - Sapir, Einat Even

AU - Levy, Shiran

AU - Yasinovsky, Kira

AU - Shkedy, Anat

AU - Zelis, Maayan

PY - 2014/5

Y1 - 2014/5

N2 - Background: Patients with Parkinson's disease have reduced gray matter volume and fractional anisotropy in both cortical and sub-cortical structures, yet changes in the pre-motor phase of the disease are unknown. Methods: A comprehensive imaging study using voxel-based morphometry and diffusion tensor imaging tract-based spatial statistics analysis was performed on 64 Ashkenazi Jewish asymptomatic first degree relatives of patients with Parkinson's disease (30 mutation carriers), who carry the G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene. Results: No between-group differences in gray matter volume could be noted in either whole-brain or volume-of-interest analysis. Diffusion tensor imaging analysis did not identify group differences in white matter areas, and volume-of-interest analysis identified no differences in diffusivity parameters in Parkinson's disease-related structures. Conclusions: G2019S carriers do not manifest changes in gray matter volume or diffusivity parameters in Parkinson's disease-related structures prior to the appearance of motor symptoms.

AB - Background: Patients with Parkinson's disease have reduced gray matter volume and fractional anisotropy in both cortical and sub-cortical structures, yet changes in the pre-motor phase of the disease are unknown. Methods: A comprehensive imaging study using voxel-based morphometry and diffusion tensor imaging tract-based spatial statistics analysis was performed on 64 Ashkenazi Jewish asymptomatic first degree relatives of patients with Parkinson's disease (30 mutation carriers), who carry the G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene. Results: No between-group differences in gray matter volume could be noted in either whole-brain or volume-of-interest analysis. Diffusion tensor imaging analysis did not identify group differences in white matter areas, and volume-of-interest analysis identified no differences in diffusivity parameters in Parkinson's disease-related structures. Conclusions: G2019S carriers do not manifest changes in gray matter volume or diffusivity parameters in Parkinson's disease-related structures prior to the appearance of motor symptoms.

KW - Diffusion tensor imaging

KW - G2019S

KW - LRRK2

KW - Magnetic resonance imaging

KW - Parkinson's disease

KW - Voxel-based morphometry

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U2 - 10.1002/mds.25827

DO - 10.1002/mds.25827

M3 - Article

C2 - 24482120

AN - SCOPUS:84899931723

SN - 0885-3185

VL - 29

SP - 823

EP - 827

JO - Movement Disorders

JF - Movement Disorders

IS - 6

ER -

A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers

Abstract

Keywords

ASJC Scopus subject areas

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