A snapshot of nature's favorite pump

Philip J. Thomas, John F. Hunt

Research output: Contribution to journalShort surveypeer-review

25 Scopus citations


The 4.5 Å map of the MsbA protein, a putative lipid A transporter from Escherichia coli, provides the first detailed structural model for the transmembrane domain and cytoplasmic 'loops' of an ABC transporter and the geometric relationship of these regions to the ATP-binding cassette motor domain. Based on this structure, specific hypotheses for the mechanics of the pump can now be formulated and tested.

Original languageEnglish (US)
Pages (from-to)920-923
Number of pages4
JournalNature Structural Biology
Issue number11
StatePublished - 2001

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics


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