A Review of Chronic Leukoencephalopathy among Survivors of Childhood Cancer

Sonia Partap, Suzanne Russo, Bijan Esfahani, Kristen Yeom, Claire Mazewski, Leanne Embry, Greg Wheeler, Nicole J. Ullrich, Daniel C. Bowers

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Currently, there are an estimated 400,000 long-term survivors of childhood cancer in the United States. Chronic leukoencephalopathy is a potential devastating late effect that can manifest as a range of neurological and neurocognitive sequelae. Survivors of the acute lymphocytic leukemia, central nervous system tumors, and stem cell transplant have frequently been exposed to cranial radiation, systemic and intrathecal chemotherapy, which places them at risk of developing chronic leukoencephalopathy. Defining leukoencephalopathy and its neuroimaging characteristics, the population of survivors at risk, its long-term consequences, and identifying prevention and intervention strategies can potentially mitigate the morbidity of these survivors. Better understanding of those at risk of leukoencephalopathy and its symptoms can lead to an improved quality of life for these cancer survivors.

Original languageEnglish (US)
Pages (from-to)2-10
Number of pages9
JournalPediatric Neurology
StatePublished - Dec 2019


  • Chemotherapy
  • Childhood cancer
  • Chronic leukoencephalopathy
  • Radiation therapy
  • Stem cell transplant
  • Survivorship

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology


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