Abstract
How does the healthy organism regulate cholesterol metabolism? The answer to this question was obtained, inter alia, by studies on patients with a genetic disease, familial hypercholesterolemia. Michael S. Brown and Joseph L. Goldstein recognized thereby the key role of the receptor for the cholesterol‐transport protein LDL. The receptor is a well‐characterized protein; studies afforded insights into endocytosis and the pathway by which the receptors enter and leave the cell. Genetic defects in the LDL receptors give rise to an accumulation of cholesterol in plasma and premature arteriosclerosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 583-602 |
| Number of pages | 20 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 25 |
| Issue number | 7 |
| DOIs | |
| State | Published - 1986 |
Keywords
- Catalysis
- Cholesterol homeostasis
- Nobel lecture
- Receptors
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)