A prospective study of motor recovery following multiple subpial transections

Lauren R. Moo, Scott D. Slotnick, Gregory Krauss, John Hart

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


A prospective study of motor recovery was undertaken in a patient scheduled to undergo multiple subpial transections (MST) of right sensorimotor cortex. Pre-transection, functional MRI (fMRI) and cortical stimulation mapping confirmed left hand motor control within right primary motor cortex. Immediately post-transection, behavioral testing demonstrated preserved strength bilaterally but decreased dexterity in the left hand. Seven weeks post-transection, dexterity returned to normal and left hand finger tapping corresponded with multiple bilateral foci of fMRI activation. At 16 weeks, fMRI activation returned to pre-transection levels. These data indicate that cortical injury due to MST resulted in the temporary recruitment of distant cortical sites which presumably subserved normal motor function during recovery.

Original languageEnglish (US)
Pages (from-to)665-669
Number of pages5
Issue number5
StatePublished - Apr 16 2002


  • Cortex
  • Cortical stimulation
  • Epilepsy
  • Human
  • Motor
  • Plasticity
  • Recovery
  • Reorganization
  • Surgery
  • fMRI

ASJC Scopus subject areas

  • General Neuroscience


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