A Practical Guide to the Pearls and Pitfalls of PSMA PET Imaging

Andrew F. Voter; Rudolf A. Werner; Hatice Savas; Andrei Gafita; Ashley E. Ross; Michael A. Gorin; Lilja B. Solnes; Martin G. Pomper; Steven P. Rowe; Sara Sheikhbahaei

doi:10.1053/j.semnuclmed.2023.11.001

A Practical Guide to the Pearls and Pitfalls of PSMA PET Imaging

Andrew F. Voter, Rudolf A. Werner, Hatice Savas, Andrei Gafita, Ashley E. Ross, Michael A. Gorin, Lilja B. Solnes, Martin G. Pomper, Steven P. Rowe, Sara Sheikhbahaei

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Prostate-specific membrane antigen (PSMA)-targeted PET agents have revolutionized the care of patients with prostate cancer, supplanting traditional methods of imaging prostate cancer, and improving the selection and delivery of therapies. This has led to a rapid expansion in both the number of PSMA PET scans performed and the imaging specialists required to interpret those scans. To aid those imagers and clinicians who are new to the interpretation of PSMA PET, this review provides an overview of the interpretation of PSMA PET/CT imaging and pearls for overcoming commonly encountered pitfalls. We discuss the physiologic distribution of the clinically available PSMA-targeted radiotracers, the commonly encountered patterns of prostate cancer spread, as well as the benign and malignant mimics of prostate cancer. Additionally, we review the standardized PSMA PET reporting systems and the role of PSMA in selecting appropriate patients for PSMA-targeted therapies.

Original language	English (US)
Pages (from-to)	119-131
Number of pages	13
Journal	Seminars in Nuclear Medicine
Volume	54
Issue number	1
DOIs	https://doi.org/10.1053/j.semnuclmed.2023.11.001
State	Published - Jan 2024
Externally published	Yes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1053/j.semnuclmed.2023.11.001

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title = "A Practical Guide to the Pearls and Pitfalls of PSMA PET Imaging",

abstract = "Prostate-specific membrane antigen (PSMA)-targeted PET agents have revolutionized the care of patients with prostate cancer, supplanting traditional methods of imaging prostate cancer, and improving the selection and delivery of therapies. This has led to a rapid expansion in both the number of PSMA PET scans performed and the imaging specialists required to interpret those scans. To aid those imagers and clinicians who are new to the interpretation of PSMA PET, this review provides an overview of the interpretation of PSMA PET/CT imaging and pearls for overcoming commonly encountered pitfalls. We discuss the physiologic distribution of the clinically available PSMA-targeted radiotracers, the commonly encountered patterns of prostate cancer spread, as well as the benign and malignant mimics of prostate cancer. Additionally, we review the standardized PSMA PET reporting systems and the role of PSMA in selecting appropriate patients for PSMA-targeted therapies.",

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AU - Ross, Ashley E.

AU - Gorin, Michael A.

AU - Solnes, Lilja B.

AU - Pomper, Martin G.

AU - Rowe, Steven P.

AU - Sheikhbahaei, Sara

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AB - Prostate-specific membrane antigen (PSMA)-targeted PET agents have revolutionized the care of patients with prostate cancer, supplanting traditional methods of imaging prostate cancer, and improving the selection and delivery of therapies. This has led to a rapid expansion in both the number of PSMA PET scans performed and the imaging specialists required to interpret those scans. To aid those imagers and clinicians who are new to the interpretation of PSMA PET, this review provides an overview of the interpretation of PSMA PET/CT imaging and pearls for overcoming commonly encountered pitfalls. We discuss the physiologic distribution of the clinically available PSMA-targeted radiotracers, the commonly encountered patterns of prostate cancer spread, as well as the benign and malignant mimics of prostate cancer. Additionally, we review the standardized PSMA PET reporting systems and the role of PSMA in selecting appropriate patients for PSMA-targeted therapies.

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A Practical Guide to the Pearls and Pitfalls of PSMA PET Imaging

Abstract

ASJC Scopus subject areas

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